caa a22 4500 445876182 CHVBK 20180317145528.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s10593-011-0847-4 doi (NATIONALLICENCE)springer-10.1007/s10593-011-0847-4 Synthesis of novel 1,3,4-oxadiazole derivatives and their nucleoside analogs with antioxidant and antitumor activities [Elektronische Daten] [A. Fadda, A. Abdel-Rahman, W. El-Sayed, T. Zidan, F. Badria] A series of new (1,3,4-oxadiazol-2-yl)-1H-benzo[h]quinolin-4-one derivatives were synthesized, including glucose and xylose hydrazones that were obtained by the reaction of hydrazides with monosaccharides. Cyclization of the sugar hydrazones with acetic anhydride afforded substituted oxadiazoline derivatives. The newly synthesized compounds were evaluated for their antioxidant properties and cytotoxicity, and showed moderate to high activities. Springer Science+Business Media, Inc., 2011 acyclic nucleosides nationallicence 1,3,4-oxadiazoles nationallicence sugar hydrazones nationallicence antioxidant activity nationallicence cytotoxicity nationallicence Fadda A. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt aut Abdel-Rahman A. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt aut El-Sayed W. Department of Photochemistry, National Research Center, El-Dokki, Cairo, Egypt aut Zidan T. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt aut Badria F. Department of Drugs, Faculty of Pharmacology, Mansoura University, Mansoura, Egypt aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/7(2011-10-01), 856-864 0009-3122 47:7<856 2011 47 10593 https://doi.org/10.1007/s10593-011-0847-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0847-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fadda A. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 700 1- Abdel-Rahman A. Department of Chemistry, Faculty of Science, Menoufia University, Shebin El-Koam, Egypt aut NATIONALLICENCE 700 1- El-Sayed W. Department of Photochemistry, National Research Center, El-Dokki, Cairo, Egypt aut NATIONALLICENCE 700 1- Zidan T. Department of Chemistry, Faculty of Science, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 700 1- Badria F. Department of Drugs, Faculty of Pharmacology, Mansoura University, Mansoura, Egypt aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/7(2011-10-01), 856-864 0009-3122 47:7<856 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer