caa a22 4500 445876417 CHVBK 20180317145529.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10593-011-0758-4 doi (NATIONALLICENCE)springer-10.1007/s10593-011-0758-4 Alkylation of 3-aminoisocarbostyryl derivatives [Elektronische Daten] [L. Potikha, R. Gutsul, V. Kovtunenko, A. Turov] The alkylation of derivatives of 3-aminoisoquinolin-1(2H)-one in the presence of NaH may proceed in three directions: 1) at the carbonyl group oxygen atom, 2) at the nitrogen atom N-2, and 3) at the 3-amino group. The reaction of equivalent amounts of the reagents gives predominantly products of substitution at the 3-amino group. Repeated alkylation proceeds at the lactam fragment to give a mixture of O-alkyl and N-alkyl derivatives. Acylation of 3-dialkylamino- and 3-alkylanilinoisoquinolin- 1(2H)-ones in the presence of NaH gave derivatives of 3-amino-1-isoquinolinyl 4-ethoxybenzoate. Springer Science+Business Media, Inc., 2011 3-aminoisocarbostyryl nationallicence 3-amino-1-isoquinolinol nationallicence enamine nationallicence isoquinoline nationallicence alkylation nationallicence Potikha L. Taras Shevchenko National University, 64 Volodyimirska St., 01033, Kyiv, Ukraine aut Gutsul R. UkrOrgSynthesis, 29 Shchorsa St., 01133, Kyiv, Ukraine aut Kovtunenko V. Taras Shevchenko National University, 64 Volodyimirska St., 01033, Kyiv, Ukraine aut Turov A. Taras Shevchenko National University, 64 Volodyimirska St., 01033, Kyiv, Ukraine aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/3(2011-06-01), 309-315 0009-3122 47:3<309 2011 47 10593 https://doi.org/10.1007/s10593-011-0758-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0758-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Potikha L. Taras Shevchenko National University, 64 Volodyimirska St., 01033, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Gutsul R. UkrOrgSynthesis, 29 Shchorsa St., 01133, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Kovtunenko V. Taras Shevchenko National University, 64 Volodyimirska St., 01033, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Turov A. Taras Shevchenko National University, 64 Volodyimirska St., 01033, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/3(2011-06-01), 309-315 0009-3122 47:3<309 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer