caa a22 4500 445876654 CHVBK 20180317145529.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10593-011-0865-2 doi (NATIONALLICENCE)springer-10.1007/s10593-011-0865-2 Synthesis of alkyl hexahydropyrazino-[1,2- c ]pyrimidine-9-carboxylates [Elektronische Daten] [M. Vovk, O. Kushnir, N. Melˈnichenko, I. Tsymbal] Cyclocondensation of 3-alkoxycarbonylmethylidenepiperazin-2-ones with α-chlorobenzyl isocyanates gave alkyl 8-aryl-1,6-dioxo-1,3,4,6,7,8-hexahydro-2H-pyrazino[1,2-c]pyrimidine-9-carboxylates. The use of 1-aryl-2,2,2-trifluoroethyl isocyanates in an analogous cyclization gave 6-aryl-1,8-dioxo-6-trifluoromethyl-1,3,4,6,7,8-hexahydro-2H-pyrazino[1,2-c]pyrimidine-9-carboxylates. Springer Science+Business Media, Inc., 2011 3-alkoxycarbonylmethylidenepiperazin-2-ones nationallicence 1-aryl-2,2,2-trifluoroethyl isocyanates nationallicence α-chlorobenzyl isocyanates nationallicence pyrazino[1,2- c ]pyrimidine-9-carboxylates nationallicence cyclocondensation nationallicence Vovk M. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., 02094, Kyiv, Ukraine aut Kushnir O. Yu. Fedkovich Chernivtsi National University, 2 Kotsyubinsky St., 58012, Chernivtsi, Ukraine aut Melˈnichenko N. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., 02094, Kyiv, Ukraine aut Tsymbal I. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., 02094, Kyiv, Ukraine aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/8(2011-11-01), 989-995 0009-3122 47:8<989 2011 47 10593 https://doi.org/10.1007/s10593-011-0865-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0865-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Vovk M. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., 02094, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Kushnir O. Yu. Fedkovich Chernivtsi National University, 2 Kotsyubinsky St., 58012, Chernivtsi, Ukraine aut NATIONALLICENCE 700 1- Melˈnichenko N. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., 02094, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Tsymbal I. Institute of Organic Chemistry, National Academy of Sciences of Ukraine, 5 Murmanska St., 02094, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/8(2011-11-01), 989-995 0009-3122 47:8<989 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer