caa a22 4500 44587676X CHVBK 20180317145530.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10593-011-0869-y doi (NATIONALLICENCE)springer-10.1007/s10593-011-0869-y Synthesis and some properties of 5-alkylamino-2-(phthalimidoalkyl)-1,3-oxazole-4-carbonitriles [Elektronische Daten] [S. Chumachenko, O. Shablykin, A. Vasilenko, V. Brovarets] 5-Alkylamino-1,3-oxazole-4-carbonitriles containing a 2-phthalimidoethyl or 3-phthalimidopropyl substituent at position 2 of the oxazole ring were synthesized. In the reaction of 5-(morpholin-4-yl)-2-(2-phthalimidoethy)l-1,3-oxazole-4-carbonitrile with hydrazine hydrate, 2-(2-aminoethyl)-5-(morpholin-4-yl)-1,3-oxazole-4-carbonitrile is formed. In the case of the 3-phthalimidopropyl analog, the recyclization product 3-amino-2-(morpholin-4-ylcarbonyl)-6,7-dihydro-5H-pyrrolo[1,2-a]imidazole is formed. Springer Science+Business Media, Inc., 2011 5-alkylamino-2-(phthalimidoalkyl)-1,3-oxazole-4-carbonitriles nationallicence 2-(2-aminoethyl)-5-(morpholin-4-yl)-1,3-oxazole-4-carbonitrile nationallicence 2-(morpholin-4-ylcarbonyl)-6,7-dihydro-5 H -pyrrolo[1,2- a ]imidazole-3-amine nationallicence recyclization nationallicence Chumachenko S. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., 02660, Kyiv, Ukraine aut Shablykin O. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., 02660, Kyiv, Ukraine aut Vasilenko A. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., 02660, Kyiv, Ukraine aut Brovarets V. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., 02660, Kyiv, Ukraine aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/8(2011-11-01), 1020-1028 0009-3122 47:8<1020 2011 47 10593 https://doi.org/10.1007/s10593-011-0869-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0869-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Chumachenko S. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., 02660, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Shablykin O. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., 02660, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Vasilenko A. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., 02660, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Brovarets V. Institute of Bioorganic Chemistry and Petrochemistry, National Academy of Sciences of Ukraine, 1 Murmanska St., 02660, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/8(2011-11-01), 1020-1028 0009-3122 47:8<1020 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer