caa a22 4500 445876808 CHVBK 20180317145530.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s10593-011-0872-3 doi (NATIONALLICENCE)springer-10.1007/s10593-011-0872-3 New method for the synthesis of 4,5-dihydro-1,4-benzothiazepin-3( 2H )-ones derivatives [Elektronische Daten] [T. Volovnenko, T. Tarasiuk, Yu. Volovenko, T. Tkachuk] A new method has been developed for the synthesis of 4,5-dihydro-1,4-benzothazepin-3(2H)ones derivatives by the acylation of N-substituted 2-chloro-5-nitrobenzylamines with acetylmercaptoacetyl chloride and α-acetylmercaptopropionyl chloride with subsequent removal of the S-acetyl protecting group and intramolecular nucleophilic substitution. The oxidation of 4,5-dihydro-1,4-benzothiazepin-3(2H)-ones to the corresponding 1,1-dioxides has been investigated. Springer Science+Business Media, Inc., 2011 4,5-dihydro-1,4-benzothiazepin-3( 2H )-one 1,1-dioxides nationallicence 4,5-dihydro-1,4-benzothiazepin-3( 2H )-ones nationallicence acylation nationallicence intramolecular nucleophilic substitution nationallicence Volovnenko T. Taras Shevchenko Kyiv National University, 64 Volodymyrska St., 01601, Kyiv, Ukraine aut Tarasiuk T. Taras Shevchenko Kyiv National University, 64 Volodymyrska St., 01601, Kyiv, Ukraine aut Volovenko Yu Taras Shevchenko Kyiv National University, 64 Volodymyrska St., 01601, Kyiv, Ukraine aut Tkachuk T. Taras Shevchenko Kyiv National University, 64 Volodymyrska St., 01601, Kyiv, Ukraine aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/8(2011-11-01), 1043-1047 0009-3122 47:8<1043 2011 47 10593 https://doi.org/10.1007/s10593-011-0872-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0872-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Volovnenko T. Taras Shevchenko Kyiv National University, 64 Volodymyrska St., 01601, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Tarasiuk T. Taras Shevchenko Kyiv National University, 64 Volodymyrska St., 01601, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Volovenko Yu Taras Shevchenko Kyiv National University, 64 Volodymyrska St., 01601, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Tkachuk T. Taras Shevchenko Kyiv National University, 64 Volodymyrska St., 01601, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/8(2011-11-01), 1043-1047 0009-3122 47:8<1043 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer