caa a22 4500 445876883 CHVBK 20180317145530.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10593-011-0803-3 doi (NATIONALLICENCE)springer-10.1007/s10593-011-0803-3 Effect of the solvent nature on the course of quaternization of 3,5-diethoxycarbonyl-2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine [Elektronische Daten] [K. Pajuste, M. Gosteva, D. Kaldre, M. Plotniece, B. Cekavicus, A. Sobolev, A. Priksane, G. Tirzitis, G. Duburs, A. Plotniece] The effect of the solvent nature and temperature on the quaternization of 3,5-diethoxycarbonyl-2,6-di- methyl-4-(3-pyridyl)-1,4-dihydropyridine by lipophilic alkyl bromides has been investigated. By comparison of the solvent effect (acetone, acetonitrile, and 2-butanone) on the alkylation of the pyridine fragment of 3,5-diethoxycarbonyl-2,6-dimethyl-4-(3-pyridyl)-1,4-dihydropyridine it was established that conducting the reaction in acetonitrile at 81°C is the most optimal. Springer Science+Business Media, Inc., 2011 acetone nationallicence acetonitrile nationallicence 2-butanone nationallicence 1,4-dihydropyridines nationallicence pyridinium derivatives nationallicence quaternization of pyridine nationallicence Pajuste K. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut Gosteva M. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut Kaldre D. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut Plotniece M. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut Cekavicus B. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut Sobolev A. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut Priksane A. Faculty of Chemistry, University of Latvia, 48 Kr. Valdemara Str., LV-1013, Riga, Latvia aut Tirzitis G. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut Duburs G. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut Plotniece A. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/5(2011-08-01), 597-601 0009-3122 47:5<597 2011 47 10593 https://doi.org/10.1007/s10593-011-0803-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10593-011-0803-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Pajuste K. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Gosteva M. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Kaldre D. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Plotniece M. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Cekavicus B. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Sobolev A. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Priksane A. Faculty of Chemistry, University of Latvia, 48 Kr. Valdemara Str., LV-1013, Riga, Latvia aut NATIONALLICENCE 700 1- Tirzitis G. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Duburs G. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut NATIONALLICENCE 700 1- Plotniece A. Latvian Institute of Organic Synthesis, 21 Aizkraukles Str., LV-1006, Riga, Latvia aut NATIONALLICENCE 773 0- Chemistry of Heterocyclic Compounds Springer US; http://www.springer-ny.com 47/5(2011-08-01), 597-601 0009-3122 47:5<597 2011 47 10593 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer