caa a22 4500 445877529 CHVBK 20180317145532.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11187-010-9308-1 doi (NATIONALLICENCE)springer-10.1007/s11187-010-9308-1 A polymorphism associated with entrepreneurship: evidence from dopamine receptor candidate genes [Elektronische Daten] [Nicos Nicolaou, Scott Shane, Georgina Adi, Massimo Mangino, Juliette Harris] The tendency to be an entrepreneur may be influenced by genetic variation. Sensation seeking is more common among entrepreneurs than among the general population. Twin studies show that the tendency to be an entrepreneur is heritable and that common genes influence both sensation seeking and entrepreneurial tendency (Nicolaou et al. Manag Sci 54:167-179, 2008a; Strateg Entrep J 2:7-21, 2008b). Since dopamine receptor genes have been associated with novelty seeking/sensation seeking (Benjamin et al. Nat Genet 12:81-84, 1996; Ebstein et al. Nat Genet 12:78-80, 1996; Noblett and Coccaro Curr Psychiatry Rep 7:73-80, 2005), and attention deficit hyperactivity disorder (ADHD) has been reported to occur at greater rates among entrepreneurs, we examined the association between five dopamine receptor genes and four ADHD-associated genes, with the tendency to be an entrepreneur in a sample of 1,335 individuals from the UK. We found a single nucleotide polymorphism (rs1486011) of the DRD3 gene on chromosome 3 to be significantly associated with the tendency to be an entrepreneur. This result is the first evidence of the association of a specific gene with entrepreneurship. Further studies are needed to replicate this association. Springer Science+Business Media, LLC., 2010 Behavior genetics nationallicence Entrepreneurship nationallicence Sensation-seeking nationallicence Nicolaou Nicos Department of Public and Business Administration, University of Cyprus, 1678, Nicosia, Cyprus aut Shane Scott Weatherhead School of Management, Case Western Reserve University, 11119 Bellflower Rd, 44106, Cleveland, OH, USA aut Adi Georgina Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, SE1 7EH, London, UK aut Mangino Massimo Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, SE1 7EH, London, UK aut Harris Juliette Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, SE1 7EH, London, UK aut Small Business Economics Springer US; http://www.springer-ny.com 36/2(2011-02-01), 151-155 0921-898X 36:2<151 2011 36 11187 https://doi.org/10.1007/s11187-010-9308-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11187-010-9308-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Nicolaou Nicos Department of Public and Business Administration, University of Cyprus, 1678, Nicosia, Cyprus aut NATIONALLICENCE 700 1- Shane Scott Weatherhead School of Management, Case Western Reserve University, 11119 Bellflower Rd, 44106, Cleveland, OH, USA aut NATIONALLICENCE 700 1- Adi Georgina Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, SE1 7EH, London, UK aut NATIONALLICENCE 700 1- Mangino Massimo Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, SE1 7EH, London, UK aut NATIONALLICENCE 700 1- Harris Juliette Department of Twin Research and Genetic Epidemiology, King's College London, St Thomas' Hospital Campus, SE1 7EH, London, UK aut NATIONALLICENCE 773 0- Small Business Economics Springer US; http://www.springer-ny.com 36/2(2011-02-01), 151-155 0921-898X 36:2<151 2011 36 11187 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer