caa a22 4500 445878266 CHVBK 20180317145534.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11030-010-9229-6 doi (NATIONALLICENCE)springer-10.1007/s11030-010-9229-6 The Gewald multicomponent reaction [Elektronische Daten] [Yijun Huang, Alexander Dömling] The Gewald reaction of sulfur, cyanoacetic acid derivatives, and oxo-component (G-3CR) yielding highly substituted 2-aminothiophene derivatives has seen diverse applications in combinatorial and medicinal chemistry. Its products are of great use in pharmaceutical industry mainly as small molecular weight inhibitors. We herein review synthetic scope and variations, usage, and structural biology of Gewald products. Springer Science+Business Media B.V., 2010 Gewald three-component reaction nationallicence Multicomponent reaction nationallicence 2-Aminothiophene nationallicence Sulfur nationallicence Cyanoacetamide nationallicence Malonodinitrile nationallicence Structure-activity relationship nationallicence Multicomponent reaction nationallicence MCR nationallicence G-3CR : Gewald three-component reaction nationallicence MCR : Multicomponent reactions nationallicence PknG : Protein kinase G nationallicence IKK β : I$${\kappa}$$ B kinase β nationallicence HT : Hydrotalcite nationallicence MPS : Morpholine-polysulfide nationallicence PEG : Polyethylene glycol nationallicence PTP1B : Protein tyrosine phosphatase 1B nationallicence IL : Ionic liquid nationallicence MW : Microwave irradiation nationallicence hGCGR : Human glucagon receptor nationallicence TNF- α : Tumor necrosis factor-α nationallicence JNK : c-Jun N-terminal kinase nationallicence KSP : Kinesin spindle protein nationallicence PDE : Phosphodiesterase enzyme nationallicence Huang Yijun Department of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, 15261, Pittsburgh, PA, USA aut Dömling Alexander Department of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, 15261, Pittsburgh, PA, USA aut Molecular Diversity Springer Netherlands 15/1(2011-02-01), 3-33 1381-1991 15:1<3 2011 15 11030 https://doi.org/10.1007/s11030-010-9229-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9229-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Huang Yijun Department of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, 15261, Pittsburgh, PA, USA aut NATIONALLICENCE 700 1- Dömling Alexander Department of Pharmaceutical Sciences and Chemistry, University of Pittsburgh, 15261, Pittsburgh, PA, USA aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/1(2011-02-01), 3-33 1381-1991 15:1<3 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer