caa a22 4500 445878339 CHVBK 20180317145534.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11030-010-9253-6 doi (NATIONALLICENCE)springer-10.1007/s11030-010-9253-6 Aminoheterocycles as synthons for combinatorial Biginelli reactions [Elektronische Daten] [Sergey Ryabukhin, Andrey Plaskon, Sergey Boron, Dmitriy Volochnyuk, Andrey Tolmachev] Chlorotrimethylsilane (TMSCl) has been utilized as an efficient promoter and water scavenger in the synthesis of diverse dihydropyrimidines via Biginelli type MCR-heterocyclization using aminoheterocycles. High yields and a simple workup of target compounds enable the facile generation of combinatorial libraries comprising more than 2,000 compounds of high structural and functional diversity. A representative set of 89 compounds is described. Springer Science+Business Media B.V., 2010 Aminoheterocycles nationallicence Dihydropyrimidines nationallicence Chlorotrimethylsilane nationallicence Biginelli reaction nationallicence Multicomponent reaction nationallicence MCR nationallicence Combinatorial nationallicence Library nationallicence Ryabukhin Sergey Enamine Ltd, 23 A. Matrosova St., 01103, Kyiv, Ukraine aut Plaskon Andrey Enamine Ltd, 23 A. Matrosova St., 01103, Kyiv, Ukraine aut Boron Sergey Enamine Ltd, 23 A. Matrosova St., 01103, Kyiv, Ukraine aut Volochnyuk Dmitriy Enamine Ltd, 23 A. Matrosova St., 01103, Kyiv, Ukraine aut Tolmachev Andrey National Taras Shevchenko University, 62 Volodymyrska St., 01033, Kyiv, Ukraine aut Molecular Diversity Springer Netherlands 15/1(2011-02-01), 189-195 1381-1991 15:1<189 2011 15 11030 https://doi.org/10.1007/s11030-010-9253-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9253-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ryabukhin Sergey Enamine Ltd, 23 A. Matrosova St., 01103, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Plaskon Andrey Enamine Ltd, 23 A. Matrosova St., 01103, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Boron Sergey Enamine Ltd, 23 A. Matrosova St., 01103, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Volochnyuk Dmitriy Enamine Ltd, 23 A. Matrosova St., 01103, Kyiv, Ukraine aut NATIONALLICENCE 700 1- Tolmachev Andrey National Taras Shevchenko University, 62 Volodymyrska St., 01033, Kyiv, Ukraine aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/1(2011-02-01), 189-195 1381-1991 15:1<189 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer