caa a22 4500 445878355 CHVBK 20180317145534.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11030-010-9227-8 doi (NATIONALLICENCE)springer-10.1007/s11030-010-9227-8 Quat-2L: a web-server for predicting protein quaternary structural attributes [Elektronische Daten] [Xuan Xiao, Pu Wang, Kuo-Chen Chou] By hybridizing the functional-domain and sequence-correlated pseudo amino acid composition approaches, a 2-layer predictor called "Quat-2L” was developed for predicting the quaternary structural attribute of a protein according to its sequence information alone. The 1st layer is to identify the query protein as monomer, homo-oligomer, or hetero-oligomer. If the result thus obtained turns out to be homo-oligomer or hetero-oligomer, then the prediction will be automatically continued to further identify it belonging to one of the following six subtypes: (1) dimer, (2) trimer, (3) tetramer, (4) pentamer, (5) hexamer, and (6) octamer. The overall success rate of Quat-2L for the 1st layer identification was 71.14%; while the overall success rates of the 2nd layer for homo-oligomers and hetero-oligomers were 76.91 and 82.52%, respectively. These rates were derived by the jackknife cross-validation tests on the stringent benchmark data set in which none of proteins has ≥60% pairwise sequence identity to any other in the same subset. As a web-server, Quat-2L is freely accessible to the public via http://icpr.jci.jx.cn/bioinfo/Quat-2L, where one can get 2-level results in about 15s. Springer Science+Business Media B.V., 2010 SMART nationallicence Function domain composition nationallicence Pseudo amino acid composition nationallicence Complexity measure factor nationallicence Fuzzy K nearest neighbor nationallicence Xiao Xuan Computer Department, Jing-De-Zhen Ceramic Institute, 333001, Jing-De-Zhen, China aut Wang Pu Computer Department, Jing-De-Zhen Ceramic Institute, 333001, Jing-De-Zhen, China aut Chou Kuo-Chen Gordon Life Science Institute, 13784 Torrey Del Mar Drive, 92130, San Diego, CA, USA aut Molecular Diversity Springer Netherlands 15/1(2011-02-01), 149-155 1381-1991 15:1<149 2011 15 11030 https://doi.org/10.1007/s11030-010-9227-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9227-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Xiao Xuan Computer Department, Jing-De-Zhen Ceramic Institute, 333001, Jing-De-Zhen, China aut NATIONALLICENCE 700 1- Wang Pu Computer Department, Jing-De-Zhen Ceramic Institute, 333001, Jing-De-Zhen, China aut NATIONALLICENCE 700 1- Chou Kuo-Chen Gordon Life Science Institute, 13784 Torrey Del Mar Drive, 92130, San Diego, CA, USA aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/1(2011-02-01), 149-155 1381-1991 15:1<149 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer