caa a22 4500 44587841X CHVBK 20180317145534.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11030-010-9261-6 doi (NATIONALLICENCE)springer-10.1007/s11030-010-9261-6 Silica-supported sulfonic acid-functionalized ionic liquid coated with [bmim][PF6] as a scavenger for the synthesis of amides [Elektronische Daten] [Li-Qin Kang, Yue-Qin Cai, Yan-Qing Peng, Xi-Li Ying, Gong-Hua Song] The methodology of using a silica gel-supported functionalized ionic liquid as a scavenger in the purification of parallel synthesis products was demonstrated. Silica-supported sulfonic acid-functional ionic liquid was synthesized by etherification, aminate, and quaternary aminate from activated silica gel and 3-chloropropyl trimethoxysilane, imidazole, and 1,4-butanesultone, which was followed by acidification using trifluoromethanesulfonic acid and anion exchange with potassium hexafluorophosphate. A conventional ionic liquid, 1-butyl-3-methylimidazolium hexafluorophosphate was then used to coat the surface of the silica gel. The silica-supported functionalized ionic liquid was used as a scavenger in the removal of excess amine in the parallel synthesis of amides. Desired products were obtained in excellent yields and purity with a sequestration time of less than 100min at room temperature. After scavenging, the scavenger was easily filtered out and regenerated. Springer Science+Business Media B.V., 2010 Silica-supported nationallicence Functionalized ionic liquid nationallicence Scavenger nationallicence Parallel synthesis nationallicence Kang Li-Qin Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China aut Cai Yue-Qin School of Chemistry and Molecular Engineering, East China University of Science and Technology, 200237, Shanghai, China aut Peng Yan-Qing Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China aut Ying Xi-Li Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China aut Song Gong-Hua Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China aut Molecular Diversity Springer Netherlands 15/1(2011-02-01), 109-113 1381-1991 15:1<109 2011 15 11030 https://doi.org/10.1007/s11030-010-9261-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9261-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kang Li-Qin Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China aut NATIONALLICENCE 700 1- Cai Yue-Qin School of Chemistry and Molecular Engineering, East China University of Science and Technology, 200237, Shanghai, China aut NATIONALLICENCE 700 1- Peng Yan-Qing Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China aut NATIONALLICENCE 700 1- Ying Xi-Li Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China aut NATIONALLICENCE 700 1- Song Gong-Hua Shanghai Key Laboratory of Chemical Biology, School of Pharmacy, East China University of Science and Technology, 200237, Shanghai, China aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/1(2011-02-01), 109-113 1381-1991 15:1<109 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer