caa a22 4500 445878444 CHVBK 20180317145534.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s11030-010-9241-x doi (NATIONALLICENCE)springer-10.1007/s11030-010-9241-x Facile synthesis of indole- or benzofuran-fused benzo[a]carbazole-1,4-diones using a tandem two-step reaction sequence [Elektronische Daten] [Shanghui Tu, Chunyong Ding, Wenxiang Hu, Fulong Li, Qizheng Yao, Ao Zhang] An efficient three-step approach was developed to assemble indole- or benzofuran-fused benzocarbazole-1,4-diones in 42-53% overall yield. This approach includes AgOAc-promoted oxidative cyclization of 2,6-di-bromocyclohexene-1,4-dione with indol-3-ylpropanoid acid, condensation of the resulting bromocarbazole intermediates with phenols or anilines, followed by Pd(OAc)-catalyzed cyclization. Such convenient synthetic protocol and the novelty of the corresponding products will largely assist our drug design and development program. Graphical Abstract: Springer Science+Business Media B.V., 2010 Carbazole nationallicence Anticancer nationallicence Tandem reaction nationallicence Coupling reaction nationallicence Cyclization nationallicence Tu Shanghui Department of Chemistry, Capital Normal University, 100048, Beijing, China aut Ding Chunyong Synthetic Organic and Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), 201203, Shanghai, China aut Hu Wenxiang Department of Chemistry, Capital Normal University, 100048, Beijing, China aut Li Fulong Synthetic Organic and Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), 201203, Shanghai, China aut Yao Qizheng Department of Medicinal Chemistry, China Pharmaceutical University, 21009, Nanjing, China aut Zhang Ao Synthetic Organic and Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), 201203, Shanghai, China aut Molecular Diversity Springer Netherlands 15/1(2011-02-01), 91-99 1381-1991 15:1<91 2011 15 11030 https://doi.org/10.1007/s11030-010-9241-x text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9241-x text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Tu Shanghui Department of Chemistry, Capital Normal University, 100048, Beijing, China aut NATIONALLICENCE 700 1- Ding Chunyong Synthetic Organic and Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), 201203, Shanghai, China aut NATIONALLICENCE 700 1- Hu Wenxiang Department of Chemistry, Capital Normal University, 100048, Beijing, China aut NATIONALLICENCE 700 1- Li Fulong Synthetic Organic and Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), 201203, Shanghai, China aut NATIONALLICENCE 700 1- Yao Qizheng Department of Medicinal Chemistry, China Pharmaceutical University, 21009, Nanjing, China aut NATIONALLICENCE 700 1- Zhang Ao Synthetic Organic and Medicinal Chemistry Laboratory (SOMCL), Shanghai Institute of Materia Medica (SIMM), 201203, Shanghai, China aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/1(2011-02-01), 91-99 1381-1991 15:1<91 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer