caa a22 4500 445878517 CHVBK 20180317145535.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s11030-010-9276-z doi (NATIONALLICENCE)springer-10.1007/s11030-010-9276-z Highly selective deuteration of pharmaceutically relevant nitrogen-containing heterocycles: a flow chemistry approach [Elektronische Daten] [Sándor Ötvös, István Mándity, Ferenc Fülöp] A simple and efficient flow-based technique is reported for the catalytic deuteration of several model nitrogen-containing heterocyclic compounds which are important building blocks of pharmacologically active materials. A continuous flow reactor was used in combination with on-demand pressure-controlled electrolytic D2 production. The D2 source was D2O, the consumption of which was very low. The experimental set-up allows the fine-tuning of pressure, temperature, and flow rate so as to determine the optimal conditions for the deuteration reactions. The described procedure lacks most of the drawbacks of the conventional batch deuteration techniques, and additionally is highly selective and reproducible. Springer Science+Business Media B.V., 2010 Deuteration nationallicence Flow chemistry nationallicence Heterogeneous catalysis nationallicence Nitrogen-containing heterocycles nationallicence Reduction nationallicence Ötvös Sándor Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, 6720, Szeged, Hungary aut Mándity István Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, 6720, Szeged, Hungary aut Fülöp Ferenc Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, 6720, Szeged, Hungary aut Molecular Diversity Springer Netherlands 15/3(2011-08-01), 605-611 1381-1991 15:3<605 2011 15 11030 https://doi.org/10.1007/s11030-010-9276-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9276-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ötvös Sándor Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, 6720, Szeged, Hungary aut NATIONALLICENCE 700 1- Mándity István Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, 6720, Szeged, Hungary aut NATIONALLICENCE 700 1- Fülöp Ferenc Institute of Pharmaceutical Chemistry, University of Szeged, Eötvös utca 6, 6720, Szeged, Hungary aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/3(2011-08-01), 605-611 1381-1991 15:3<605 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer