caa a22 4500 445878630 CHVBK 20180317145535.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s11030-010-9295-9 doi (NATIONALLICENCE)springer-10.1007/s11030-010-9295-9 Application of continuous flow and alternative energy devices for 5-hydroxymethylfurfural production [Elektronische Daten] [Michael Schön, Michael Schnürch, Marko Mihovilovic] Dehydration of fructose and glucose in dipolar, aprotic solvents leads to formation of 5-hydroxymethylfurfural. Conditions for continuous flow reactions using a cartridge-based reactor system and a stop-flow microwave reactor were established showing very good product yields and selectivity without the limitation of a batch process such as upscaling and precise temperature monitoring and control. A maximum product HPLC yield of 90.3% under cartridge-based heating and 85.6% under microwave heating could be achieved using mild and quick reaction conditions. Formation of levulinic acid as a by-product could not be detected under the optimized reaction conditions. Springer Science+Business Media B.V., 2011 Flow chemistry nationallicence Carbohydrate dehydration nationallicence 5-Hydroxymethylfurfural nationallicence Cartridge-based reactors nationallicence Stopped-flow microwave nationallicence DMSO : Dimethylsulfoxide nationallicence HMF : 5-Hydroxymethylfurfural nationallicence HPLC : High performance liquid chromatography nationallicence IL : Ionic liquid nationallicence μW : Microwave (conditions) nationallicence NHC : N-heterocyclic carbene nationallicence PDA : Photodiode array nationallicence RI : Refractive index nationallicence TFA : Trifluoroacetic acid nationallicence Schön Michael Institute for Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163, 1060, Vienna, Austria aut Schnürch Michael Institute for Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163, 1060, Vienna, Austria aut Mihovilovic Marko Institute for Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163, 1060, Vienna, Austria aut Molecular Diversity Springer Netherlands 15/3(2011-08-01), 639-643 1381-1991 15:3<639 2011 15 11030 https://doi.org/10.1007/s11030-010-9295-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9295-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Schön Michael Institute for Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Schnürch Michael Institute for Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163, 1060, Vienna, Austria aut NATIONALLICENCE 700 1- Mihovilovic Marko Institute for Applied Synthetic Chemistry, Vienna University of Technology, Getreidemarkt 9/163, 1060, Vienna, Austria aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/3(2011-08-01), 639-643 1381-1991 15:3<639 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer