caa a22 4500 445878746 CHVBK 20180317145535.0 cr unu---uuuuu 170323e20111101xx s 000 0 eng 10.1007/s11030-011-9319-0 doi (NATIONALLICENCE)springer-10.1007/s11030-011-9319-0 Targeting tuberculosis through a small focused library of 1,2,3-triazoles [Elektronische Daten] [Guillermo Labadie, Agustina de la Iglesia, Héctor Morbidoni] Looking for new active molecules against Mycobacterium tuberculosis, a small focused library of 1,2,3-triazoles was efficiently prepared by click chemistry. Compounds were subsequently tested against different pathogenic and opportunistic mycobacteria including M. avium and M. tuberculosis. Two of them showed MIC at lowerμg/mL concentration for M. avium and even below that for M. tuberculosis, being more potent that control drugs. Springer Science+Business Media B.V., 2011 Tuberculosis nationallicence Triazoles nationallicence Click chemistry nationallicence Labadie Guillermo Instituto de Química Rosario (IQUIR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK, Rosario, Argentina aut de la Iglesia Agustina Catedra de Microbiología, Virología y Parasitología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, S2002KTR, Rosario, Argentina aut Morbidoni Héctor Catedra de Microbiología, Virología y Parasitología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, S2002KTR, Rosario, Argentina aut Molecular Diversity Springer Netherlands 15/4(2011-11-01), 1017-1024 1381-1991 15:4<1017 2011 15 11030 https://doi.org/10.1007/s11030-011-9319-0 text/html Onlinezugriff via DOI 1 brief-communication jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-011-9319-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Labadie Guillermo Instituto de Química Rosario (IQUIR-CONICET), Facultad de Ciencias Bioquímicas y Farmacéuticas, Universidad Nacional de Rosario, Suipacha 531, S2002LRK, Rosario, Argentina aut NATIONALLICENCE 700 1- de la Iglesia Agustina Catedra de Microbiología, Virología y Parasitología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, S2002KTR, Rosario, Argentina aut NATIONALLICENCE 700 1- Morbidoni Héctor Catedra de Microbiología, Virología y Parasitología, Facultad de Ciencias Médicas, Universidad Nacional de Rosario, Santa Fe 3100, S2002KTR, Rosario, Argentina aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/4(2011-11-01), 1017-1024 1381-1991 15:4<1017 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer