caa a22 4500 445878932 CHVBK 20180317145536.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s11030-010-9272-3 doi (NATIONALLICENCE)springer-10.1007/s11030-010-9272-3 A diversity-oriented synthesis of pyrazolo[4,3- f ]quinoline derivatives with potential bioactivities via microwave-assisted multi-component reactions [Elektronische Daten] [Feng Shi, Shu Zhang, Shan-Shan Wu, Yuan Gao, Shu-Jiang Tu] Six new series of pyrazolo[4,3-f]quinoline derivatives with potential bioactivities were synthesized by the three-component reactions of aromatic aldehydes, 5-aminoindazole, and various cyclic 1,3-dicarbonyl compounds under microwave irradiation. This protocol has the valuable features of structural diversity of products, broader substrate scope, operational simplicity, high yields, and short reaction time. Moreover, the structure of compound 88a was confirmed by an X-ray crystallographic analysis and attested to the chemoselectivity of reaction where 1-methyl barbituric acid participated. Springer Science+Business Media B.V., 2010 Pyrazolo[4,3- f ]quinoline derivatives nationallicence Diversity-oriented synthesis nationallicence Multi-component reactions nationallicence Microwave irradiation nationallicence MW nationallicence DOS nationallicence MCR nationallicence Shi Feng School of Chemistry and Chemical Engineering, Xuzhou Normal University, 221116, Xuzhou, Jiangsu, People's Republic of China aut Zhang Shu Clinical Research Center, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, Jiangsu, People's Republic of China aut Wu Shan-Shan School of Chemistry and Chemical Engineering, Xuzhou Normal University, 221116, Xuzhou, Jiangsu, People's Republic of China aut Gao Yuan College of Chemistry and Chemical Engineering, Shenzhen University, 518060, Shenzhen, Guangdong, People's Republic of China aut Tu Shu-Jiang School of Chemistry and Chemical Engineering, Xuzhou Normal University, 221116, Xuzhou, Jiangsu, People's Republic of China aut Molecular Diversity Springer Netherlands 15/2(2011-05-01), 497-505 1381-1991 15:2<497 2011 15 11030 https://doi.org/10.1007/s11030-010-9272-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9272-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Shi Feng School of Chemistry and Chemical Engineering, Xuzhou Normal University, 221116, Xuzhou, Jiangsu, People's Republic of China aut NATIONALLICENCE 700 1- Zhang Shu Clinical Research Center, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, Jiangsu, People's Republic of China aut NATIONALLICENCE 700 1- Wu Shan-Shan School of Chemistry and Chemical Engineering, Xuzhou Normal University, 221116, Xuzhou, Jiangsu, People's Republic of China aut NATIONALLICENCE 700 1- Gao Yuan College of Chemistry and Chemical Engineering, Shenzhen University, 518060, Shenzhen, Guangdong, People's Republic of China aut NATIONALLICENCE 700 1- Tu Shu-Jiang School of Chemistry and Chemical Engineering, Xuzhou Normal University, 221116, Xuzhou, Jiangsu, People's Republic of China aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/2(2011-05-01), 497-505 1381-1991 15:2<497 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer