caa a22 4500 445878991 CHVBK 20180317145536.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s11030-010-9287-9 doi (NATIONALLICENCE)springer-10.1007/s11030-010-9287-9 A diversity-oriented synthesis of 3-(2-amino-1,6-dihydro-6-oxo-pyrimidin-5-yl)propanoic esters [Elektronische Daten] [Xavier Berzosa, Sofia Pettersson, Jordi Teixidó, José Borrell] The synthesis of dimethyl 2-(methoxymethylene) pentanedioates by an unusual Michael addition of 3,3-dimethoxypropionate to α, β-unsaturated esters is described. These new intermediates can subsequently be converted to methyl 3-(2-amino-1,6-dihydro-6-oxo-pyrimidin-5-yl)propanoates upon treatment with guanidine carbonate. The resulting pyrimidine derivatives are open-chain analogues of pyrido[2,3-d]pyrimidines with interesting biological activities. Springer Science+Business Media B.V., 2010 Michael addition nationallicence α , β -Unsaturated ester nationallicence Methyl 3,3-dimethoxypropionate nationallicence Pyrimidin-5-ylpropanoic acids nationallicence Microwave synthesis nationallicence Berzosa Xavier Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain aut Pettersson Sofia Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain aut Teixidó Jordi Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain aut Borrell José Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain aut Molecular Diversity Springer Netherlands 15/2(2011-05-01), 595-601 1381-1991 15:2<595 2011 15 11030 https://doi.org/10.1007/s11030-010-9287-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9287-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Berzosa Xavier Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain aut NATIONALLICENCE 700 1- Pettersson Sofia Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain aut NATIONALLICENCE 700 1- Teixidó Jordi Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain aut NATIONALLICENCE 700 1- Borrell José Grup d'Enginyeria Molecular, Institut Químic de Sarrià, Universitat Ramon Llull, Via Augusta 390, 08017, Barcelona, Spain aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/2(2011-05-01), 595-601 1381-1991 15:2<595 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer