caa a22 4500 445879009 CHVBK 20180317145536.0 cr unu---uuuuu 170323e20110501xx s 000 0 eng 10.1007/s11030-010-9275-0 doi (NATIONALLICENCE)springer-10.1007/s11030-010-9275-0 A novel four-component reaction for the synthesis of disubstituted 1,3,4-oxadiazole derivatives [Elektronische Daten] [Ali Ramazani, Nahid Shajari, Amir Mahyari, Yavar Ahmadi] The 1:1 imine intermediate generated by the addition of benzyl amine to cyclobutanone is trapped by (N-isocyanimino)triphenylphosphorane in the presence of an aromatic carboxylic acid leads to the formation of the corresponding iminophosphorane intermediate. Disubstituted 1,3,4-oxadiazole derivatives are formed via intramolecular aza-Wittig reaction of the iminophosphorane intermediate. The reactions were completed in neutral conditions at room temperature. The disubstituted 1,3,4-oxadiazole derivatives, were produced in excellent yields. Springer Science+Business Media B.V., 2010 ( N -isocyanimino)triphenylphosphorane nationallicence Aromatic carboxylic acid nationallicence Cyclobutanone nationallicence Benzyl amine nationallicence 1,3,4-oxadiazole nationallicence aza -Wittig reaction nationallicence 4CC nationallicence MCR nationallicence Ramazani Ali Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran aut Shajari Nahid Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran aut Mahyari Amir Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran aut Ahmadi Yavar Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran aut Molecular Diversity Springer Netherlands 15/2(2011-05-01), 521-527 1381-1991 15:2<521 2011 15 11030 https://doi.org/10.1007/s11030-010-9275-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s11030-010-9275-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ramazani Ali Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran aut NATIONALLICENCE 700 1- Shajari Nahid Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran aut NATIONALLICENCE 700 1- Mahyari Amir Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran aut NATIONALLICENCE 700 1- Ahmadi Yavar Chemistry Department, Zanjan University, PO Box 45195-313, Zanjan, Iran aut NATIONALLICENCE 773 0- Molecular Diversity Springer Netherlands 15/2(2011-05-01), 521-527 1381-1991 15:2<521 2011 15 11030 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer