caa a22 4500 445879424 CHVBK 20180317145537.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00604-010-0510-2 doi (NATIONALLICENCE)springer-10.1007/s00604-010-0510-2 Wang Yazhen School of Chemistry and Environmental Engineering, Jianghan University, 430056, Wuhan, China aut The electrochemistry of uric acid at a gold electrode modified with L-cysteine, and its application to sensing uric urine [Elektronische Daten] [Yazhen Wang] The electrochemistry of uric acid at a gold electrode modified with a self-assembled film of L-cysteine was studied by cyclic voltammetry and differential pulse voltammetry. Compared to the bare gold electrode, uric acid showed better electrochemical response in that the anodic peak current is stronger and the peak potential is negatively shifted by about 100mV. The effects of experimental conditions on the oxidation of uric acid were tested and a calibration plot was established. The differential pulse response to uric acid is linear in the concentration range from 1.0 × 10−6 to ~ 1.0 × 10−4mol⋅L−1 (r = 0.9995) and from 1.0 × 10−4 to ~ 5.0 × 10−4mol⋅L−1 (r = 0.9990), the detection limit being 1.0 × 10−7mol⋅L−1 (at S/N = 3). The high sensitivity and good selectivity of the electrode was demonstrated by its practical application to the determination of uric acid in urine samples. Cyclic voltammograms of UA at the bare electrode (a,b) and the L-Cys/Au electrode (c,d,e) in HAc-NaAc buffer containing different concentrations of UA. (a,c): blank; (b, d): 2.0 × 10−5mol⋅L−1; (e) 4.0 × 10−5mol⋅L−1. Scan rate: 100mV⋅s−1 Springer-Verlag, 2010 Uric acid nationallicence Modified electrode nationallicence L-cysteine nationallicence Voltammetry nationallicence Urine nationallicence Microchimica Acta Springer Vienna 172/3-4(2011-03-01), 419-424 0026-3672 172:3-4<419 2011 172 604 https://doi.org/10.1007/s00604-010-0510-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-010-0510-2 text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Wang Yazhen School of Chemistry and Environmental Engineering, Jianghan University, 430056, Wuhan, China aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 172/3-4(2011-03-01), 419-424 0026-3672 172:3-4<419 2011 172 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer