caa a22 4500 445879548 CHVBK 20180317145538.0 cr unu---uuuuu 170323e20110301xx s 000 0 eng 10.1007/s00604-010-0497-8 doi (NATIONALLICENCE)springer-10.1007/s00604-010-0497-8 Improving the synthesis of a molecularly imprinted sol-gel for serine using a Plackett-Burman design [Elektronische Daten] [Alfonso Fernández-González, Rosana Badía-Laíño, Marta Díaz-García] We have studied the influence of the experimental conditions during synthesis on the properties of molecularly imprinted sol-gels for serine. The influence of hydrophobicity, presence of amino groups, additives, water/ethanol ratio and type of catalyst (basic or acid) were optimized using a Plackett-Burmann design in 12 blocks. Serine was selected as a target molecule for the imprinting process, and each imprinted and non-imprinted material was studied by competitive and non-competitive protocols. The results demonstrate the strong effect of 3-aminopropyltrimethoxysilane on the recognition capabilities of the materials in competitive assays. The mechanisms of interaction appear to be similar in acid-catalysed sol-gels, whereas sol-gels obtained under base catalysis tend to give interactions affecting the competitive experiments only. Figure Suggested interaction mechanism between 3-APTEOS containing xero-gels and serine. Springer-Verlag, 2010 Molecular imprinting nationallicence MIP nationallicence Serine nationallicence Plackett-Burman nationallicence Fernández-González Alfonso Departament of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Av. Julián Clavería, 8, 33006, Oviedo, Spain aut Badía-Laíño Rosana Departament of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Av. Julián Clavería, 8, 33006, Oviedo, Spain aut Díaz-García Marta Departament of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Av. Julián Clavería, 8, 33006, Oviedo, Spain aut Microchimica Acta Springer Vienna 172/3-4(2011-03-01), 351-356 0026-3672 172:3-4<351 2011 172 604 https://doi.org/10.1007/s00604-010-0497-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-010-0497-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Fernández-González Alfonso Departament of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Av. Julián Clavería, 8, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Badía-Laíño Rosana Departament of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Av. Julián Clavería, 8, 33006, Oviedo, Spain aut NATIONALLICENCE 700 1- Díaz-García Marta Departament of Physical and Analytical Chemistry, Faculty of Chemistry, University of Oviedo, Av. Julián Clavería, 8, 33006, Oviedo, Spain aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 172/3-4(2011-03-01), 351-356 0026-3672 172:3-4<351 2011 172 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer