caa a22 4500 445879785 CHVBK 20180317145539.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00604-010-0459-1 doi (NATIONALLICENCE)springer-10.1007/s00604-010-0459-1 Towards a monolithically integrated microsystem based on the green tape ceramics technology for spectrophotometric measurements. Determination of chromium (VI) in water [Elektronische Daten] [Ricardo Alves-Segundo, Núria Ibañez-Garcia, Mireia Baeza, Mar Puyol, Julián Alonso-Chamarro] A general procedure is presented for the fabrication of miniaturized continuous flow analytical microsystems based on photometric detection using the low temperature co-fired ceramics technology. Optical elements such as light emitting diodes and photodiodes (all in the size of a few hundred micrometers) are integrated by means of an off-chip approach. A simple procedure is demonstrated to integrate a glass window after the ceramic sintering in order to minimize the decrease in sensitivity due to the reduction of the optical path length when scaling down. A flow cell with a shape of a bubble has been used to increase the area of the light beam. The device is robust, affordable, and small-sized. It enables absorbance measurements to be performed in-situ or for continuous monitoring of environmental samples. Specifically, a microsystem is introduced for colorimetric determination of chromium (VI) ion in waters based on the diphenylcarbazide reagent as a model. Under the optimized conditions, a linear response is obtained for the concentration range from 0.1 to 20mgL−1, with a detection limit of 50μgL−1. Springer-Verlag, 2010 Low-temperature co-fired ceramics nationallicence Microanalyzer nationallicence Photometric detection nationallicence Chromium (VI) nationallicence Diphenylcarbazide nationallicence Alves-Segundo Ricardo Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Centro Regional do Porto, Campus da Asprela, 4200-072, Porto, Portugal aut Ibañez-Garcia Núria Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autónoma de Barcelona, 08193, Bellaterra (Cerdanyola del Vallès), Spain aut Baeza Mireia Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autónoma de Barcelona, 08193, Bellaterra (Cerdanyola del Vallès), Spain aut Puyol Mar Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autónoma de Barcelona, 08193, Bellaterra (Cerdanyola del Vallès), Spain aut Alonso-Chamarro Julián Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autónoma de Barcelona, 08193, Bellaterra (Cerdanyola del Vallès), Spain aut Microchimica Acta Springer Vienna 172/1-2(2011-02-01), 225-232 0026-3672 172:1-2<225 2011 172 604 https://doi.org/10.1007/s00604-010-0459-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-010-0459-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Alves-Segundo Ricardo Escola Superior de Biotecnologia, Universidade Católica Portuguesa, Centro Regional do Porto, Campus da Asprela, 4200-072, Porto, Portugal aut NATIONALLICENCE 700 1- Ibañez-Garcia Núria Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autónoma de Barcelona, 08193, Bellaterra (Cerdanyola del Vallès), Spain aut NATIONALLICENCE 700 1- Baeza Mireia Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autónoma de Barcelona, 08193, Bellaterra (Cerdanyola del Vallès), Spain aut NATIONALLICENCE 700 1- Puyol Mar Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autónoma de Barcelona, 08193, Bellaterra (Cerdanyola del Vallès), Spain aut NATIONALLICENCE 700 1- Alonso-Chamarro Julián Grup de Sensors i Biosensors, Departament de Química, Facultat de Ciències, Edifici C-Nord, Universitat Autónoma de Barcelona, 08193, Bellaterra (Cerdanyola del Vallès), Spain aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 172/1-2(2011-02-01), 225-232 0026-3672 172:1-2<225 2011 172 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer