caa a22 4500 445879831 CHVBK 20180317145539.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00604-010-0454-6 doi (NATIONALLICENCE)springer-10.1007/s00604-010-0454-6 Simultaneous determination of multi-class antibiotic residues in water using carrier-mediated hollow-fiber liquid-phase microextraction coupled with ultra-high performance liquid chromatography tandem mass spectrometry [Elektronische Daten] [Soparat Yudthavorasit, Chayada Chiaochan, Natchanun Leepipatpiboon] A method has been developed for carrier-mediated hollow-fiber liquid-phase microextraction (HF-LPME) and enrichment of multiple classes of antibiotics in water samples. Eleven compounds (erythromycin, spiramycin, tilmicosin, sulfathiazole, sulfamethazine, sulfamerazine, oxytetracycline, tetracycline, ciprofloxacin, danofloxacin and enrofloxacin) from four important classes of antibiotics (of the macrolide, sulfonamide, tetracycline and quinolone type) have been simultaneously preconcentrated with one set of HF-LPME conditions, followed by determination by ultra-HPLC combined with electrospray ionization tandem mass spectrometry (UHPLC-MS/MS). Antibiotics can be determined at ng L−1 levels using this highly sensitive and selective method. Parameters including immersion time, liquid membrane composition, sample pH, acceptor composition and extraction time were optimized to finally give detection limits in the 10-250ngL−1 range. Good linearity was achieved, with up to 156 times enrichment over the four classes of antibiotics. This multi-residue method enabled the simultaneous enrichment of all 11 multi-class antibiotics from spiked river water samples, with relative recovery between 79 and 118%. Figure Carrier-mediated HF-LPME was utilized only one condition to simultaneously extract and enrich multi-class antibiotics in water with UHPLC-MS/MS detection providing high sensitivity and selectivity. Springer-Verlag, 2010 Antibiotic nationallicence Residues nationallicence Carrier-mediated nationallicence Hollow fiber nationallicence Liquid-phase microextraction nationallicence Sample preparation nationallicence Yudthavorasit Soparat Chromatography and Separation Research Unit, Department of Chemistry, Chulalongkorn University, 10330, Bangkok, Thailand aut Chiaochan Chayada Chromatography and Separation Research Unit, Department of Chemistry, Chulalongkorn University, 10330, Bangkok, Thailand aut Leepipatpiboon Natchanun Chromatography and Separation Research Unit, Department of Chemistry, Chulalongkorn University, 10330, Bangkok, Thailand aut Microchimica Acta Springer Vienna 172/1-2(2011-02-01), 39-49 0026-3672 172:1-2<39 2011 172 604 https://doi.org/10.1007/s00604-010-0454-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-010-0454-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yudthavorasit Soparat Chromatography and Separation Research Unit, Department of Chemistry, Chulalongkorn University, 10330, Bangkok, Thailand aut NATIONALLICENCE 700 1- Chiaochan Chayada Chromatography and Separation Research Unit, Department of Chemistry, Chulalongkorn University, 10330, Bangkok, Thailand aut NATIONALLICENCE 700 1- Leepipatpiboon Natchanun Chromatography and Separation Research Unit, Department of Chemistry, Chulalongkorn University, 10330, Bangkok, Thailand aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 172/1-2(2011-02-01), 39-49 0026-3672 172:1-2<39 2011 172 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer