caa a22 4500 445879890 CHVBK 20180317145539.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s00604-010-0484-0 doi (NATIONALLICENCE)springer-10.1007/s00604-010-0484-0 New integrated in vivo microdialysis-electrochemical device for determination of the neurotransmitter dopamine in rat striatum of freely moving rats [Elektronische Daten] [Li Lin, Yuepiao Cai, Ruipo Lin, Li Yu, Caiyong Song, Hongchang Gao, Xiaokun Li] A new kind of device was developed based on integrating in-vivo microdialysis with electrochemical microsensing. It can be applied to in-vivo determination of dopamine in rat striatum of freely moving rats. The microsensor was fabricated by electrochemically depositing a film containing overoxidized polypyrrole and multi-wall carbon nanotubes onto a carbon fiber microelectrode. It causes efficient and selective electrocatalytic oxidation of dopamine and displays relatively good stability and lifetime. The oxidation currents for dopamine are linear in the concentration range from 5.0 nM to 10 μM, and the detection limit (at S/N = 3) is 0.5 nM. The integrated device was successfully applied to assessing the impact of an endogenous donor of nitric oxide (sodium nitroprusside) on the concentration of dopamine in striatum of moving rats. This is of significance to understand the physiological basis of Parkinson's disease. Figure New integrated in vivo microdialysis-electrochemical device for determination of the neurotransmitter dopamine in rat striatum of freely moving rats Springer-Verlag, 2010 In vivo microdialysis nationallicence Microsensor nationallicence Dopamine nationallicence Overoxidized polypyrrole nationallicence Multi-wall carbon nanotube nationallicence Lin Li School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut Cai Yuepiao School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut Lin Ruipo School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut Yu Li School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut Song Caiyong School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut Gao Hongchang School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut Li Xiaokun School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut Microchimica Acta Springer Vienna 172/1-2(2011-02-01), 217-223 0026-3672 172:1-2<217 2011 172 604 https://doi.org/10.1007/s00604-010-0484-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-010-0484-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Lin Li School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut NATIONALLICENCE 700 1- Cai Yuepiao School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut NATIONALLICENCE 700 1- Lin Ruipo School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut NATIONALLICENCE 700 1- Yu Li School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut NATIONALLICENCE 700 1- Song Caiyong School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut NATIONALLICENCE 700 1- Gao Hongchang School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut NATIONALLICENCE 700 1- Li Xiaokun School of Pharmacy, Wenzhou Medical College, 325035, Wenzhou, People's Republic of China aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 172/1-2(2011-02-01), 217-223 0026-3672 172:1-2<217 2011 172 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer