caa a22 4500 445880236 CHVBK 20180317145540.0 cr unu---uuuuu 170323e20111001xx s 000 0 eng 10.1007/s00604-011-0670-8 doi (NATIONALLICENCE)springer-10.1007/s00604-011-0670-8 Electrochemiluminescence detection system for microchip capillary electrophoresis and its application to pharmaceutical analysis [Elektronische Daten] [Hui Yang, Xin-chun Li, Fan Yang, Jun Feng, Miao-yin Lin, Zuan-guang Chen] We describe an efficient and easily fabricated electrochemiluminescence detection system for microchip capillary electrophoresis. A 300-μm-diameter platinum disc working electrode was embedded in a titanium tube which provides an adequate holding for working electrode and acts as counter electrode. We also have designed a simplified detection cell with a guide channel for the electrode. The integrated working-counter electrode can be easily aligned to the outlet of the separation channel through the guide channel. The functionality of the system was demonstrated by separation and detection of proline and tripropylamine. The response to proline is linear in the range from 5μM to 5,000μM, and the detection limit is 1.0μM (S/N = 3). The system was further applied to the determination of chlorpromazine hydrochloride in pharmaceutical formulations. The system is believed to have potential applications in pharmaceutical analysis. Figure We described an efficient and easily fabricated electrochemiluminescence detection system for microchip capillary electrophoresis. The functionality of the system was demonstrated by separation and detection of proline and tripropylamine. The response to proline is linear in the range from 5μM to 5,000μM, and the detection limit is 1.0μM (S/N = 3). Springer-Verlag, 2011 Electrochemiluminescence detection nationallicence Microchip capillary electrophoresis nationallicence Tris (2, 2′-bipyridyl)-ruthenium (II) nationallicence Chlorpromazine hydrochloride nationallicence Yang Hui School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut Li Xin-chun School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut Yang Fan School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut Feng Jun School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut Lin Miao-yin School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut Chen Zuan-guang School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut Microchimica Acta Springer Vienna 175/1-2(2011-10-01), 193-199 0026-3672 175:1-2<193 2011 175 604 https://doi.org/10.1007/s00604-011-0670-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-011-0670-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yang Hui School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut NATIONALLICENCE 700 1- Li Xin-chun School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut NATIONALLICENCE 700 1- Yang Fan School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut NATIONALLICENCE 700 1- Feng Jun School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut NATIONALLICENCE 700 1- Lin Miao-yin School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut NATIONALLICENCE 700 1- Chen Zuan-guang School of Pharmaceutical Sciences, Sun Yat-sen University, 510006, Guangzhou, People's Republic China aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 175/1-2(2011-10-01), 193-199 0026-3672 175:1-2<193 2011 175 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer