caa a22 4500 445880503 CHVBK 20180317145541.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s00604-011-0568-5 doi (NATIONALLICENCE)springer-10.1007/s00604-011-0568-5 Sensitive voltammetric determination of rutin in pharmaceuticals, human serum, and traditional Chinese medicines using a glassy carbon electrode coated with graphene nanosheets, chitosan, and a poly(amido amine) dendrimer [Elektronische Daten] [Huanshun Yin, Yunlei Zhou, Lin Cui, Tao Liu, Peng Ju, Lusheng Zhu, Shiyun Ai] The electrochemical behavior of rutin was investigated in pH 6.0 buffer solution using a glassy carbon electrode coated with graphene nanosheets, chitosan and a poly (amidoamine) dendrimer in pH6.0 buffer solution. The results indicate that the modified electrode displays electrochemical redox activity towards rutin, and that the oxidation peak current of rutin increases significantly compared to that at other electrodes. The amount of immobilized graphene and dendrimer, pH value, scan rate, accumulation time and accumulation potential were optimized. The kinetic parameters, charge transfer coefficient, transfer electron number, proton transfer number, standard rate constant, were calculated. Under the optimized conditions, the oxidation peak current is proportional to the concentration of rutin in the range between 0.001 and 2.0μmol L−1 (R = 0.9991). The detection limit is 0.6nmol L−1 (at S/N = 3). The electrode exhibits satisfactory selectivity and reproducibility and was applied to the determination of rutin in pharmaceutical preparations, spiked human serum, and traditional Chinese medicine, with recoveries between 97.2 and 104.67%. Figure 1. Preparation of graphene nanosheets and PAMAM modified glassy carbon electrode. 2. Graphene nanosheets and PAMAM improve the electrochemical redox of rutin. 3. The prepared electrode determines rutine with high sensitivity and selectivity. 4. The developed method can determine rutin in pharmaceutical formulations, human serum, and traditional Chinese medicine. Springer-Verlag, 2011 Graphene nanosheets nationallicence Poly(amido amine) dendrimer nationallicence Rutin nationallicence Cyclic voltammetry nationallicence Differential pulse voltammetry nationallicence Yin Huanshun College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut Zhou Yunlei College of Life Science, Beijing Normal University, 100875, Beijing, China aut Cui Lin College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut Liu Tao College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut Ju Peng College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut Zhu Lusheng College of Resources and Environment, Shandong Agricultural University, 271018, Taian, Shandong, China aut Ai Shiyun College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut Microchimica Acta Springer Vienna 173/3-4(2011-06-01), 337-345 0026-3672 173:3-4<337 2011 173 604 https://doi.org/10.1007/s00604-011-0568-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-011-0568-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yin Huanshun College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut NATIONALLICENCE 700 1- Zhou Yunlei College of Life Science, Beijing Normal University, 100875, Beijing, China aut NATIONALLICENCE 700 1- Cui Lin College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut NATIONALLICENCE 700 1- Liu Tao College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut NATIONALLICENCE 700 1- Ju Peng College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut NATIONALLICENCE 700 1- Zhu Lusheng College of Resources and Environment, Shandong Agricultural University, 271018, Taian, Shandong, China aut NATIONALLICENCE 700 1- Ai Shiyun College of Chemistry and Material Science, Shandong Agricultural University, 271018, Taian, Shandong, China aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 173/3-4(2011-06-01), 337-345 0026-3672 173:3-4<337 2011 173 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer