caa a22 4500 445880953 CHVBK 20180317145543.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00604-010-0542-7 doi (NATIONALLICENCE)springer-10.1007/s00604-010-0542-7 Determination of N-acetylcysteine via its effect on the aggregation of gold nanoparticles [Elektronische Daten] [Marina Sierra-Rodero, Juan Fernández-Romero, Agustina Gómez-Hens] The effect of thiol compounds on the kinetics of the aggregation of gold nanoparticles in the presence of the cationic surfactant cetyltrimethyl ammonium bromide has been studied. It was applied to the determination of N-acetylcysteine using the stopped-flow mixing technique along with light scattering detection. The signal obtained was measured after about 5s, and gave the analytical information for a calibration graph in the concentration range from 2.9 to 60μmolL−1 of N-acetylcysteine, and a detection limit of 0.87μmolL−1. The effect of other thiols on the system is also described. The relative standard deviation ranges between 0.6% and 3.5%. The method was applied to the determination of N-acetylcysteine in several pharmaceutical samples with recoveries that range from 97.7% to 101.1%. Figure S1, S2: stopped-flow driving syringes Springer-Verlag, 2011 Gold nanoparticles nationallicence Kinetic nationallicence Light-scattering nationallicence N-acetylcysteine nationallicence Pharmaceutical preparations nationallicence Sierra-Rodero Marina Department of Analytical Chemistry, University of Córdoba, Marie Curie Annex Building, Campus of Rabanales, 14071, Córdoba, Spain aut Fernández-Romero Juan Department of Analytical Chemistry, University of Córdoba, Marie Curie Annex Building, Campus of Rabanales, 14071, Córdoba, Spain aut Gómez-Hens Agustina Department of Analytical Chemistry, University of Córdoba, Marie Curie Annex Building, Campus of Rabanales, 14071, Córdoba, Spain aut Microchimica Acta Springer Vienna 173/1-2(2011-04-01), 11-17 0026-3672 173:1-2<11 2011 173 604 https://doi.org/10.1007/s00604-010-0542-7 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-010-0542-7 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sierra-Rodero Marina Department of Analytical Chemistry, University of Córdoba, Marie Curie Annex Building, Campus of Rabanales, 14071, Córdoba, Spain aut NATIONALLICENCE 700 1- Fernández-Romero Juan Department of Analytical Chemistry, University of Córdoba, Marie Curie Annex Building, Campus of Rabanales, 14071, Córdoba, Spain aut NATIONALLICENCE 700 1- Gómez-Hens Agustina Department of Analytical Chemistry, University of Córdoba, Marie Curie Annex Building, Campus of Rabanales, 14071, Córdoba, Spain aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 173/1-2(2011-04-01), 11-17 0026-3672 173:1-2<11 2011 173 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer