caa a22 4500 445881089 CHVBK 20180317145543.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00604-010-0537-4 doi (NATIONALLICENCE)springer-10.1007/s00604-010-0537-4 Synthesis of p-aminothiophenol-embedded gold/silver core-shell nanostructures as novel SERS tags for biosensing applications [Elektronische Daten] [Zhihui Luo, Kun Chen, Donglian Lu, Heyou Han, Mingqiang Zou] We describe a novel surface-enhanced Raman scattering (SERS) tag that is based on Au/Ag core-shell nanostructures embedded with p-aminothiophenol. The Au/Ag core-shell sandwich nanostructures demonstrate bright and dark stripe structure and possess very strong SERS activity. Under optimum conditions, the maximum SERS signal was obtained with a 10nm thick Ag nanoshell, and the enhancement factor is 3.4 × 104 at 1077cm−1. After conjugation to the antibody of muramidase releasing protein (MRP), the Au/Ag core-shell nanostructures were successfully applied to an SERS-based detection scheme for MRP based on a sandwich type of immunoassay. Figure A novel SERS tag of p-Aminothiophenol (pATP) embedded Au/Ag core-shell nanostructures were prepared by adding precursor solution (AgNO3) into the original Au nanoparticles (NPs) solution. The synthesized SERS tags, as a biosensers, were further applied to detect a biomarker protein of SS2 Springer-Verlag, 2011 Au/Ag core-shell nanostructures nationallicence Surface enhanced Raman scattering nationallicence Biosensing nationallicence Immunoassay nationallicence Muramidase released protein nationallicence Luo Zhihui College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut Chen Kun College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut Lu Donglian College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut Han Heyou College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut Zou Mingqiang Chinese Academy of Inspection and Quarantine, 100025, Beijing, People's Republic of China aut Microchimica Acta Springer Vienna 173/1-2(2011-04-01), 149-156 0026-3672 173:1-2<149 2011 173 604 https://doi.org/10.1007/s00604-010-0537-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-010-0537-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Luo Zhihui College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Chen Kun College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Lu Donglian College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Han Heyou College of Science, State Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, 430070, Wuhan, People's Republic of China aut NATIONALLICENCE 700 1- Zou Mingqiang Chinese Academy of Inspection and Quarantine, 100025, Beijing, People's Republic of China aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 173/1-2(2011-04-01), 149-156 0026-3672 173:1-2<149 2011 173 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer