caa a22 4500 445881119 CHVBK 20180317145543.0 cr unu---uuuuu 170323e20110401xx s 000 0 eng 10.1007/s00604-010-0501-3 doi (NATIONALLICENCE)springer-10.1007/s00604-010-0501-3 A novel anti-interference and pH-modulation device: application to enzyme-free glucose detection [Elektronische Daten] [Yuhua Su, Rongzong Hu, Weixiong Huang, Kangkang Hu] We report on a novel anti-interference and pH-modulation device (herein after referred to as "device”). It is based on electrodialysis and can continuously increase the pH value of the carrier solution and - at the same time - remove interfering analytical signals obtained for ascorbic acid (AA) and uric acid (UA). The "device” was coupled to the FIA-amperometric detection of glucose. The linear range is from 1μmolL−1 to 0.4mmolL−1, with a sensitivity of 213μAcm−2mM−1 and a detection limit of 1μmolL−1 at a signal-to-noise ratio of 3. The method was used to sucessfully determine glucose in serum. This study represents a novel technique for overcoming analytical interference and is expected to find applications in liquid chromatography, for example in on-line pH-modulation if different pH values are needed for separation and detection. Figure As shown in the figure, a specific electrolytic current was applied between the two electrodes. Thus H2O in the cathode chamber was electrolyzed to produce H2 and OH-. Then the OH- moved through the anion exchange membrane and got into the packed column by electromigration, where it mixed with the carrier solution of Na2SO4. Meanwhile, the SO42- of the carrier solution moved through the other anion exchange membrane and entered the anode chamber. Therefore, the carrier solution of Na2SO4 was partly converted into NaOH after passing through the "device”. Springer-Verlag, 2010 Anti-interference nationallicence pH-modulation nationallicence Electrodialysis nationallicence Glucose nationallicence FIA-amperometric detection nationallicence Su Yuhua The Key Laboratory of Analytical Science of Xiamen University, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China aut Hu Rongzong The Key Laboratory of Analytical Science of Xiamen University, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China aut Huang Weixiong The Key Laboratory of Analytical Science of Xiamen University, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China aut Hu Kangkang The Key Laboratory of Analytical Science of Xiamen University, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China aut Microchimica Acta Springer Vienna 173/1-2(2011-04-01), 19-26 0026-3672 173:1-2<19 2011 173 604 https://doi.org/10.1007/s00604-010-0501-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-010-0501-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Su Yuhua The Key Laboratory of Analytical Science of Xiamen University, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China aut NATIONALLICENCE 700 1- Hu Rongzong The Key Laboratory of Analytical Science of Xiamen University, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China aut NATIONALLICENCE 700 1- Huang Weixiong The Key Laboratory of Analytical Science of Xiamen University, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China aut NATIONALLICENCE 700 1- Hu Kangkang The Key Laboratory of Analytical Science of Xiamen University, College of Chemistry and Chemical Engineering, Xiamen University, 361005, Xiamen, China aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 173/1-2(2011-04-01), 19-26 0026-3672 173:1-2<19 2011 173 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer