caa a22 4500 445881534 CHVBK 20180317145545.0 cr unu---uuuuu 170323e20110701xx s 000 0 eng 10.1007/s00604-011-0612-5 doi (NATIONALLICENCE)springer-10.1007/s00604-011-0612-5 Analysis of narcotic drugs in biological samples using hollow fiber liquid-phase microextraction and gas chromatography with nitrogen phosphorus detection [Elektronische Daten] [Mohammad Saraji, Maliheh Boroujeni] We report on a method for trace analysis of the narcotic drugs alfentanil, fentanyl, and sufentanil in plasma and urine. Two-phase hollow fiber liquid-phase microextraction was combined with GC using nitrogen-phosphorus detection. Experimental parameters were optimized to give a viable analytical procedure whose limits of detection range from 8 to 15ng L−1 (at an S/N of 3). The calibration curves are linear between 0.1 and 50μg L−1, with squared correlation coefficients (r 2) between 0.9953 and 0.9979. Precision values range from 2.4% to 3.3% (intra-day RSD) and 3.2 to 6.3% (inter-day RSD). The relative recoveries varied from 27.8% to 84.6% (for spiked plasma) and 75 to 85.2% (for spiked urine). The method consumes little solvent, is simple, fast, inexpensive, and well suitable for the analysis of complicated matrices. Figure Schematic diagram of two phase hollow fiber liquid-phase microextraction (HF-LPME) combined with GC and nitrogen-phosphorus detection for trace analysis of the narcotic drugs alfentanil, fentanyl, and sufentanil in plasma and urine. Springer-Verlag, 2011 Hollow fiber liquid-phase microextraction nationallicence Gas chromatography nationallicence Fentanyl nationallicence Sufentanil nationallicence Alfentanil nationallicence Biological samples nationallicence Saraji Mohammad Department of Chemistry, Isfahan University of Technology, 84156-83111, Isfahan, Iran aut Boroujeni Maliheh Department of Chemistry, Isfahan University of Technology, 84156-83111, Isfahan, Iran aut Microchimica Acta Springer Vienna 174/1-2(2011-07-01), 159-166 0026-3672 174:1-2<159 2011 174 604 https://doi.org/10.1007/s00604-011-0612-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s00604-011-0612-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saraji Mohammad Department of Chemistry, Isfahan University of Technology, 84156-83111, Isfahan, Iran aut NATIONALLICENCE 700 1- Boroujeni Maliheh Department of Chemistry, Isfahan University of Technology, 84156-83111, Isfahan, Iran aut NATIONALLICENCE 773 0- Microchimica Acta Springer Vienna 174/1-2(2011-07-01), 159-166 0026-3672 174:1-2<159 2011 174 604 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer