caa a22 4500 445882301 CHVBK 20180317145547.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0359-z doi (NATIONALLICENCE)springer-10.1007/s10157-010-0359-z Tomino Yasuhiko Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut Pathogenetic and therapeutic approaches to IgA nephropathy using a spontaneous animal model, the ddY mouse [Elektronische Daten] [Yasuhiko Tomino] IgA nephropathy is the most common primary chronic glomerulonephritis in the world and was first described by Berger et al. (J Urol Nephrol 74:694-695;1968). Histopathologically, IgA nephropathy is characterized by expansion of the glomerular mesangial matrix with mesangial cell proliferation. Glomeruli typically contain generalized diffuse granular mesangial deposits of IgA (mainly IgA1), IgG and C3. In advanced patients, global glomerular sclerosis, crescent formation and tubulo-interstitial fibrosis are marked in light microscopy. IgA nephropathy is generally considered to be an immune-complex mediated glomerulonephritis. Although more than 40years have passed since this disease was firstly described, the pathogenesis/initiation factors of IgA nephropathy are still obscure. The objective of this review is to explain the pathogenesis and treatment based on our previous data of ddY mouse, a spontaneous animal model for IgA nephropathy. Japanese Society of Nephrology, 2010 ddY mouse nationallicence Pathogenesis nationallicence Treatment nationallicence IgA nephropathy nationallicence Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 1-7 1342-1751 15:1<1 2011 15 10157 https://doi.org/10.1007/s10157-010-0359-z text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0359-z text/html Onlinezugriff via DOI NATIONALLICENCE 100 1- Tomino Yasuhiko Division of Nephrology, Department of Internal Medicine, Juntendo University Faculty of Medicine, 2-1-1 Hongo, Bunkyo-ku, 113-8421, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 1-7 1342-1751 15:1<1 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer