caa a22 4500 44588231X CHVBK 20180317145547.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0350-8 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0350-8 Renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 [Elektronische Daten] [Akira Ishikawa, Hiroo Kawarazaki, Katsuyuki Ando, Megumi Fujita, Toshiro Fujita, Yukio Homma] Background: The aim of this study was to evaluate the renal preservation effect of ubiquinol, the reduced form of coenzyme Q10 (CoQ10). Methods: Three-week-old heminephrectomized male Sprague-Dawley rats were divided into three groups (10 animals each): diet with normal (0.3%) salt, high (8%) salt, and high salt plus 600mg/kg body weight/day of ubiquinol, for 4weeks. Systolic blood pressure (SBP), urinary albumin (u-alb), superoxide anion generation (lucigenin chemiluminescence) and ubiquinol levels in renal tissues were examined. Results: Salt loading increased SBP (111.0±3.6 vs. 169.4±14.3mmHg, p<0.01) and u-alb (43.8±28.0 vs. 2528.7±1379.0µg/day, p<0.02). These changes were associated with stimulation of superoxide generation in the kidney (866.3±102.8 vs. 2721.4±973.3RLU/g kidney, p<0.01). However, ubiquinol decreased SBP (143.9±29.0mmHg, p<0.05), u-alb (256.1±122.1µg/day, p<0.02), and renal superoxide production (877.8±195.6RLU/g kidney, p<0.01), associated with an increase in renal ubiquinol levels. Conclusion: Ubiquinol, the reduced form of CoQ10, effectively ameliorates renal function, probably due to its antioxidant effect. Thus, ubiquinol may be a candidate for the treatment of patients with kidney disease. Japanese Society of Nephrology, 2010 Ubiquinol nationallicence Ubiquinone nationallicence Oxidative stress nationallicence Urinary albumin nationallicence Chronic renal disease nationallicence Ishikawa Akira Department of Urology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Kawarazaki Hiroo Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Ando Katsuyuki Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Fujita Megumi Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Fujita Toshiro Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut Homma Yukio Department of Urology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 30-33 1342-1751 15:1<30 2011 15 10157 https://doi.org/10.1007/s10157-010-0350-8 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0350-8 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Ishikawa Akira Department of Urology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 700 1- Kawarazaki Hiroo Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Ando Katsuyuki Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujita Megumi Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Fujita Toshiro Department of Nephrology and Endocrinology, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Homma Yukio Department of Urology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, 113-8655, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 30-33 1342-1751 15:1<30 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer