caa a22 4500 445882336 CHVBK 20180317145547.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0372-2 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0372-2 Involvement of bone-marrow-derived cells in kidney fibrosis [Elektronische Daten] [Takashi Wada, Norihiko Sakai, Yoshio Sakai, Kouji Matsushima, Shuichi Kaneko, Kengo Furuichi] Cellular mechanisms have been proposed in the pathogenesis of fibrotic processes in the kidney. In this setting, cell sources underlying the generation of matrix-producing cells in diseased kidneys have been categorized as activated resident stromal cells (e.g., fibroblasts, pericytes), infiltrating bone-marrow-derived cells (e.g., fibrocytes, T cells, macrophages), and cells derived from epithelial-mesenchymal transition/endothelial-mesenchymal transition. Among these cell sources, accumulating evidence has shed light on the involvement of bone-marrow-derived cells, including monocytes/macrophages, and a circulating mesenchymal progenitor cell, fibrocyte, in the progression of fibrosis in kidney. Bone-marrow-derived cells positive for CD45 or CD34, and type 1 (pro)collagen dependent on the chemokine and renin-angiotensin systems migrate into diseased kidneys and enhance synthesis matrix protein, cytokines/chemokines, and profibrotic growth factors, which may promote and escalate chronic inflammatory processes and possible interaction with resident stromal cells, thereby perpetuating kidney fibrosis. Japanese Society of Nephrology, 2010 Fibrocyte nationallicence Chemokine nationallicence Fibrosis nationallicence Kidney nationallicence Fibroblast nationallicence Bone-marrow-derived cells nationallicence Wada Takashi Division of Nephrology, Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut Sakai Norihiko Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan aut Sakai Yoshio Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan aut Matsushima Kouji Department of Molecular Preventive Medicine, University of Tokyo, Tokyo, Japan aut Kaneko Shuichi Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan aut Furuichi Kengo Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 8-13 1342-1751 15:1<8 2011 15 10157 https://doi.org/10.1007/s10157-010-0372-2 text/html Onlinezugriff via DOI 1 review-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0372-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Wada Takashi Division of Nephrology, Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, 13-1 Takara-machi, 920-8641, Kanazawa, Japan aut NATIONALLICENCE 700 1- Sakai Norihiko Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan aut NATIONALLICENCE 700 1- Sakai Yoshio Department of Laboratory Medicine, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan aut NATIONALLICENCE 700 1- Matsushima Kouji Department of Molecular Preventive Medicine, University of Tokyo, Tokyo, Japan aut NATIONALLICENCE 700 1- Kaneko Shuichi Department of Disease Control and Homeostasis, Institute of Medical, Pharmaceutical and Health Sciences, Faculty of Medicine, Kanazawa University, Kanazawa, Japan aut NATIONALLICENCE 700 1- Furuichi Kengo Division of Blood Purification, Kanazawa University Hospital, Kanazawa, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 8-13 1342-1751 15:1<8 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer