caa a22 4500 445882344 CHVBK 20180317145547.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0355-3 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0355-3 Augmented antihypertensive effect of a fixed combination formula of candesartan and hydrochlorothiazide combined with furosemide in a patient on peritoneal dialysis [Elektronische Daten] [Satoru Kuriyama, Yasushi Otsuka, Hiroyuki Ueda, Naoki Sugano, Takeo Yoshizawa, Taku Yamada, Tatsuo Hosoya] A 38-year-old female patient on peritoneal dialysis (PD) due to type 1 diabetic nephropathy with a well-preserved residual renal function did not respond well to the conventional antihypertensive therapy consisting of candesartan, furosemide, and bunazosin. Switching candesartan for a fixed combination formula of candesartan plus hydrochlorothiazide (HCTZ) while the rest of the other two agents remained unchanged led to the remarkable reduction in both systolic and diastolic blood pressure (BP) without significant changes in the cardiothoracic ratio (CTR), body weight (BW), and residual renal function. This case suggests that when used in combination, diuretics acting on different functional segment of the nephron hold greater potential for enhanced antihypertensive effect, especially in patients on PD whose residual renal function is well preserved. A small dose of HCTZ with an angiotensin II receptor blocker (ARB) may partially explain the therapeutic benefit of this combination therapy in terms of a reliable hypotensive effect, a better adherence, and fewer side effects. Japanese Society of Nephrology, 2010 Hypertension nationallicence Hydrochlorothiazide nationallicence Candesartan nationallicence Furosemide nationallicence Peritoneal dialysis nationallicence Kuriyama Satoru Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut Otsuka Yasushi Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut Ueda Hiroyuki Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut Sugano Naoki Department of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan aut Yoshizawa Takeo Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut Yamada Taku Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut Hosoya Tatsuo Department of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 175-178 1342-1751 15:1<175 2011 15 10157 https://doi.org/10.1007/s10157-010-0355-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0355-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuriyama Satoru Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Otsuka Yasushi Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Ueda Hiroyuki Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Sugano Naoki Department of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 700 1- Yoshizawa Takeo Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Yamada Taku Division of Nephrology, Saiseikai Central Hospital, Jikei University School of Medicine, 1-4-17 Mita, Minato-ku, Tokyo, Japan aut NATIONALLICENCE 700 1- Hosoya Tatsuo Department of Kidney and Hypertension, Jikei University School of Medicine, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 175-178 1342-1751 15:1<175 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer