caa a22 4500 445882387 CHVBK 20180317145547.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0371-3 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0371-3 Resistive index predicts renal prognosis in chronic kidney disease: results of a 4-year follow-up [Elektronische Daten] [Toshihiro Sugiura, Akira Wada] Background: While the clinical validity of Doppler ultrasonography in chronic kidney disease (CKD) is still controversial, we have shown in a 2-year follow-up study that the resistive index (RI) could estimate renal prognosis in CKD. The purpose of the present study is to determine whether RI could predict long-term renal prognosis in CKD. Methods: We performed a 4-year follow-up study with an observational cohort of 281 CKD patients (GFR 51±31ml/min/1.73m2, age 54±17years). The patients were examined by Doppler ultrasonography for RI [(peak-systolic velocity−end-diastolic velocity)/peak-systolic velocity] to be calculated. Glomerular filtration rate (GFR) was estimated with the revised Japanese equation. Worsening renal function was defined as a decrease in GFR of at least 20ml/min/1.73m2 or the need for long-term dialysis therapy until the end of the 4-year follow-up. Results: Among the 281 CKD patients, 89 patients presented with worsening renal function during the 4-year follow-up. When we divided the patients into two groups by RI value of 0.70, Kaplan-Meier analysis showed that the event-free rates of worsening renal function at 48months were 0.86 and 0.37 in patients with RI≤0.70 and RI>0.70, respectively (log-rank test, p<0.001). Cox proportional-hazard analysis identified overt proteinuria (≥1.0g/g creatinine), high RI (>0.70), low GFR (<50ml/min/1.73m2) and high systolic blood pressure (≥140mmHg) as independent predictors of worsening renal function. Conclusions: This study demonstrated that high RI as well as proteinuria, low GFR, and hypertension were independent risk factors for the progression of CKD in the 4-year follow-up. Japanese Society of Nephrology, 2010 Chronic kidney disease nationallicence Doppler ultrasonography nationallicence Renal prognosis nationallicence Resistive index nationallicence Risk factors nationallicence Sugiura Toshihiro Department of Internal Medicine, Otemae Hospital, 1-5-34 Otemae, Chuo-ku, 540-0008, Osaka, Osaka, Japan aut Wada Akira Department of Internal Medicine, Osaka National Hospital, Osaka, Japan aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 114-120 1342-1751 15:1<114 2011 15 10157 https://doi.org/10.1007/s10157-010-0371-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0371-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sugiura Toshihiro Department of Internal Medicine, Otemae Hospital, 1-5-34 Otemae, Chuo-ku, 540-0008, Osaka, Osaka, Japan aut NATIONALLICENCE 700 1- Wada Akira Department of Internal Medicine, Osaka National Hospital, Osaka, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 114-120 1342-1751 15:1<114 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence SWISSBIB 401783294 BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer