caa a22 4500 445882425 CHVBK 20180317145547.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0346-4 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0346-4 Acute peritonitis due to Corynebacterium ulcerans in a patient receiving continuous ambulatory peritoneal dialysis: a case report and literature review [Elektronische Daten] [Yukihiro Kimura, Yasuko Watanabe, Norihiro Suga, Natsuko Suzuki, Kunihiro Maeda, Keisuke Suzuki, Wataru Kitagawa, Naoto Miura, Hiroyuki Morita, Hirokazu Imai] A 55-year-old Japanese woman receiving continuous ambulatory peritoneal dialysis (CAPD) was admitted to our service with abdominal pain and cloudy peritoneal fluid. Laboratory data revealed a white blood cell count of 7.20×109cells/L, hemoglobin 9.8g/dl, hematocrit 29.0%, platelet count 284×109cells/L, and C-reactive protein (CRP) 0.109g/L. Peritoneal fluid white blood cell count of 2,000cells/µl suggested acute peritonitis. An empiric trial of cefazolin and ceftazidime, subsequently switched to meropenem, vancomycin, minocycline, and amikacin, did not improve the patient's symptoms. The peritoneal fluid collected before initiation of antibiotic therapy grew Corynebacterium ulcerans. Ampicillin/sulbactam was started based on the culture and sensitivity data. On hospital day 8, the CAPD catheter was removed due to no clinical improvement and persistently increased levels of CRP to 0.0174g/L. A 14-day course of ampicillin/sulbactam improved her clinical condition and laboratory data. Microbiological analysis revealed that C. ulcerans isolated from this patient did not produce diphtheria toxin. C. ulcerans was not isolated from her dog's oral and nasal cavities during a search for the route of her infection. We recommend that in patients with peritoneal dialysis, special attention should be paid to Corynebacterium peritonitis, especially due to C. ulcerans, which may produce diphtheria toxin, be resistant to multiple antibiotics, and frequently become recurrent. Japanese Society of Nephrology, 2010 Acute peritonitis nationallicence Continuous ambulatory peritoneal dialysis nationallicence Corynebacterium ulcerans nationallicence Kimura Yukihiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Watanabe Yasuko Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Suga Norihiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Suzuki Natsuko Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Maeda Kunihiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Suzuki Keisuke Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Kitagawa Wataru Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Miura Naoto Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Morita Hiroyuki Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Imai Hirokazu Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 171-174 1342-1751 15:1<171 2011 15 10157 https://doi.org/10.1007/s10157-010-0346-4 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0346-4 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kimura Yukihiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Watanabe Yasuko Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Suga Norihiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Suzuki Natsuko Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Maeda Kunihiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Suzuki Keisuke Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Kitagawa Wataru Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Miura Naoto Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Morita Hiroyuki Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Imai Hirokazu Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cho, 480-1195, Aichi, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 171-174 1342-1751 15:1<171 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer