caa a22 4500 445882433 CHVBK 20180317145548.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0366-0 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0366-0 The effects of raloxifene on bone turnover markers and bone mineral density in women on maintenance hemodialysis [Elektronische Daten] [Osamu Saito, Takako Saito, Shinji Asakura, Taro Sugase, Chiharu Ito, Yasuhiro Ando, Shigeaki Muto, Eiji Kusano] Background: Bone disease is caused not only by increased bone turnover accompanying secondary hyperparathyroidism but also by factors such as bone metabolic disorder accompanying kidney disease and postmenopausal or age-related osteoporosis in hemodialysis patients. In this study, we investigated the effects of raloxifene on bone turnover markers and bone mineral density (BMD) in female hemodialysis patients to determine involvement of estrogen deficiency in bone disease. Methods: The subjects were 47 female patients on maintenance hemodialysis. Raloxifene hydrochloride (60mg) was administered to 21 patients for 1year, and these patients were compared with a control group of 26 patients. Serum levels of N-terminal cross-linking telopeptide of typeI collagen (NTx), bone alkaline phosphatase, and intact parathyroid hormone were measured, and BMD was determined by quantitative heel ultrasound as the speed of sound (SOS) in the calcaneus over this period. Results: NTx decreased after treatment with raloxifene for 1year, but significantly increased in the control group. SOS increased after treatment with raloxifene for 1year, but significantly decreased in the control group. Treatment with raloxifene resulted in a significant decrease of NTx and a significant increase of SOS in subgroups of patients aged <60 and ≥60years. Conclusions: Treatment with raloxifene can suppress a rise in NTx and increase bone mineral density in patients around the time of menopause and in postmenopausal patients of advanced age. A reduction in bone mineral density caused by estrogen deficiency may be involved in the development of bone disease in female hemodialysis patients. Japanese Society of Nephrology, 2010 Raloxifene nationallicence Hemodialysis nationallicence Postmenopausal osteoporosis nationallicence Saito Osamu Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Saito Takako Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Asakura Shinji Oyama Suginoki Clinic, 1113-1 Nakakuki, 321-0964, Oyama, Tochigi, Japan aut Sugase Taro Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Ito Chiharu Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Ando Yasuhiro Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Muto Shigeaki Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Kusano Eiji Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 126-131 1342-1751 15:1<126 2011 15 10157 https://doi.org/10.1007/s10157-010-0366-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0366-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Saito Osamu Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Saito Takako Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Asakura Shinji Oyama Suginoki Clinic, 1113-1 Nakakuki, 321-0964, Oyama, Tochigi, Japan aut NATIONALLICENCE 700 1- Sugase Taro Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Ito Chiharu Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Ando Yasuhiro Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Muto Shigeaki Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Kusano Eiji Department of Nephrology, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 126-131 1342-1751 15:1<126 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer