caa a22 4500 44588245X CHVBK 20180317145548.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0361-5 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0361-5 Association between plasma homocysteine and microalbuminuria in persons without hypertension, diabetes mellitus, and cardiovascular disease [Elektronische Daten] [Charumathi Sabanayagam, Anoop Shankar] Background: Microalbuminuria and plasma homocysteine levels are both considered to be markers of endothelial dysfunction and shown to be predictors of cardiovascular disease (CVD) in epidemiological studies. However, previous studies examining the association between plasma homocysteine and microalbuminuria have suggested that this association is explained by confounding factors such as preexisting CVD, diabetes, hypertension, and reduced kidney function. Methods: We examined the association between plasma homocysteine and microalbuminuria in a representative sample of US men and women aged ≥20years, who were free of diabetes mellitus, hypertension, and CVD and who participated in the Third National Health and Nutrition Examination Survey (n=3,948). Microalbuminuria was defined as urinary albumin-to-creatinine ratio ≥30mg/g. Results: Plasma homocysteine levels were positively associated with microalbuminuria in men but not in women (p-interaction <0.0001) after adjusting for age, race/ethnicity, smoking, drinking, body mass index, physical activity, glomerular filtration rate, blood pressure, high-density lipoprotein cholesterol, glycated hemoglobin, serum folate, serum vitamin B12, and C-reactive protein. In men, the multivariable odds ratio (OR) [95% confidence interval (CI)] of microalbuminuria comparing the highest to the lowest quartile of homocysteine was 5.17 (2.00-13.36); (p-trend=0.005). Further, men in the highest quartile of homocysteine and age ≥60years had >12-fold odds of microalbuminuria compared with men in the lowest homocysteine quartile and age <60years. In contrast, in women, the multivariable OR (95% CI) comparing the highest to the lowest quartile of homocysteine was 0.96 (0.86-1.07); (p-trend=0.41). Conclusions: Among relatively healthy adults, plasma homocysteine levels are associated with microalbuminuria only in men. Japanese Society of Nephrology, 2010 Homocysteine nationallicence Albuminuria nationallicence Gender nationallicence Sabanayagam Charumathi Department of Community Medicine, West Virginia University School of Medicine, P.O. Box 9190, 26506-9190, Morgantown, WV, USA aut Shankar Anoop Department of Community Medicine, West Virginia University School of Medicine, P.O. Box 9190, 26506-9190, Morgantown, WV, USA aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 92-99 1342-1751 15:1<92 2011 15 10157 https://doi.org/10.1007/s10157-010-0361-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0361-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Sabanayagam Charumathi Department of Community Medicine, West Virginia University School of Medicine, P.O. Box 9190, 26506-9190, Morgantown, WV, USA aut NATIONALLICENCE 700 1- Shankar Anoop Department of Community Medicine, West Virginia University School of Medicine, P.O. Box 9190, 26506-9190, Morgantown, WV, USA aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 92-99 1342-1751 15:1<92 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer