caa a22 4500 445882476 CHVBK 20180317145548.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0360-6 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0360-6 Effect of anemia on cardiac disorders in pre-dialysis patients immediately before starting hemodialysis [Elektronische Daten] [Michio Kuwahara, Soichiro Iimori, Tamaki Kuyama, Wataru Akita, Yoshihiro Mori, Tomoki Asai, Yusuke Tsukamoto, Susumu Adachi, Tatemitsu Rai, Shinichi Uchida, Sei Sasaki] Introduction: Anemia is a common complication of patients with chronic kidney disease (CKD), which not only lowers their quality of life but also potentially causes cardiovascular diseases such as congestive heart failure and coronary heart disease, and accelerates the progression of renal dysfunction. Methods: Pre-dialysis patients were assigned to groups A, B, C or D based on hemoglobin levels of ≤8.9 (n=48), 9.0-9.9 (n=63), 10-10.9 (n=53), and ≥11.0g/dL (n=39), respectively. Cardiac function was estimated using echocardiography to clarify the relationship between anemia and cardiac disorders in patients with CKD immediately before starting hemodialysis. Results: Left ventricular ejection fraction (LVEF) was significantly higher in group D than in groups A and B. The fractions with an LVEF of less than 50% were 16.7, 4.8, 1.9, and 0% in groups A, B, C, and D, respectively. Posterior wall thickness was statistically thicker and the deceleration time of the early diastolic wave was longer in groups A and B, respectively, than in groups C and D. The left ventricular mass index in group D was significantly lower than in any other groups. Conclusion: Anemia in pre-dialysis patients with CKD is a probable cause of impaired left ventricular systolic function and progressive left ventricular hypertrophy. Our results suggest that Hb levels should be maintained at >11g/dL by EPO administration from the perspective of protecting cardiac function, although the upper limit of the target Hb level was undetermined. Japanese Society of Nephrology, 2010 Chronic kidney disease nationallicence Erythropoietin nationallicence Echocardiography nationallicence Kuwahara Michio Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut Iimori Soichiro Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut Kuyama Tamaki Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut Akita Wataru Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut Mori Yoshihiro Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut Asai Tomoki Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut Tsukamoto Yusuke Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut Adachi Susumu Division of Cardiology, Shuwa General Hospital, Kasukabe, Japan aut Rai Tatemitsu Department of Nephrology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Uchida Shinichi Department of Nephrology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Sasaki Sei Department of Nephrology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 121-125 1342-1751 15:1<121 2011 15 10157 https://doi.org/10.1007/s10157-010-0360-6 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0360-6 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kuwahara Michio Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut NATIONALLICENCE 700 1- Iimori Soichiro Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut NATIONALLICENCE 700 1- Kuyama Tamaki Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut NATIONALLICENCE 700 1- Akita Wataru Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut NATIONALLICENCE 700 1- Mori Yoshihiro Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut NATIONALLICENCE 700 1- Asai Tomoki Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut NATIONALLICENCE 700 1- Tsukamoto Yusuke Division of Nephrology, Shuwa General Hospital, 1200 Yahara-Shinden, 344-0035, Kasukabe, Saitama, Japan aut NATIONALLICENCE 700 1- Adachi Susumu Division of Cardiology, Shuwa General Hospital, Kasukabe, Japan aut NATIONALLICENCE 700 1- Rai Tatemitsu Department of Nephrology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 700 1- Uchida Shinichi Department of Nephrology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 700 1- Sasaki Sei Department of Nephrology, Tokyo Medical and Dental University Graduate School, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 121-125 1342-1751 15:1<121 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer