caa a22 4500 445882514 CHVBK 20180317145548.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0365-1 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0365-1 Doubling of serum creatinine: is it appropriate as the endpoint for CKD? Proposal of a new surrogate endpoint based on the reciprocal of serum creatinine [Elektronische Daten] [Noriko Takeuchi, Emi Takenoshita, Fumino Kato, Tomoko Terajima, Makoto Ogawa, Satoshi Suzuki, Takayuki Fujii, Eriko Kobayashi, Tomoya Sakurada, Nobunori Satoh, Shiro Ueda] Background: The evaluation of the progression of renal insufficiency, or decline in glomerular filtration rate (GFR), has been approached more simply and precisely by converting measured serum creatinine value into the reciprocal of serum creatinine, estimated GFR, or other parameters. Doubling of serum creatinine (simple doubling) is conveniently used as a surrogate endpoint for progression of renal disease but is thought to be biased unfairly by the initial value of serum creatinine (ScrInt). We proposed the definite decline in the reciprocal of serum creatinine (2-4 doubling) as a surrogate endpoint, comparing simple doubling with this new endpoint to verify the effect of ScrInt on the endpoint. Methods: For the purpose of comparison between endpoints, 194 patients in a historical cohort of chronic glomerulonephritis were investigated. Kaplan-Meier survival analysis was performed with the composite endpoint of need for dialysis and either simple doubling or 2-4 doubling. Then, the distribution of ScrInt was compared between total patients and patients developing each endpoint. Results: The endpoint value of serum creatinine (ScrEnd) with 2-4 doubling was lower than that with simple doubling at ScrInt<2.00mg/dl, and the difference of ScrEnd between simple doubling and 2-4 doubling was larger, as ScrInt became lower. In patients reaching simple doubling, ScrInt was higher than that of the total patients (1.66 vs. 1.07mg/dl in median, respectively; p<0.001). In patients reaching 2-4 doubling, there was no significant difference in ScrInt. Conclusion: Patients with low serum creatinine concentration at baseline had a tendency of prolonged development into simple doubling. In contrast, with 2-4 doubling, there was no bias of ScrInt. Japanese Society of Nephrology, 2010 Chronic kidney disease nationallicence Endpoint nationallicence Doubling of serum creatinine nationallicence Takeuchi Noriko Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut Takenoshita Emi Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut Kato Fumino Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut Terajima Tomoko Department of Practical Pharmacy, Faculty of Pharmacy, Keio University, Tokyo, Japan aut Ogawa Makoto Department of Nephrology, Chiba University Hospital, Chiba, Japan aut Suzuki Satoshi Department of Nephrology, Seirei Sakura Citizen Hospital, Chiba, Japan aut Fujii Takayuki Department of Nephrology, Seirei Sakura Citizen Hospital, Chiba, Japan aut Kobayashi Eriko Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut Sakurada Tomoya Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut Satoh Nobunori Department of Clinical Education and Research, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan aut Ueda Shiro Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 100-107 1342-1751 15:1<100 2011 15 10157 https://doi.org/10.1007/s10157-010-0365-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0365-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Takeuchi Noriko Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut NATIONALLICENCE 700 1- Takenoshita Emi Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut NATIONALLICENCE 700 1- Kato Fumino Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut NATIONALLICENCE 700 1- Terajima Tomoko Department of Practical Pharmacy, Faculty of Pharmacy, Keio University, Tokyo, Japan aut NATIONALLICENCE 700 1- Ogawa Makoto Department of Nephrology, Chiba University Hospital, Chiba, Japan aut NATIONALLICENCE 700 1- Suzuki Satoshi Department of Nephrology, Seirei Sakura Citizen Hospital, Chiba, Japan aut NATIONALLICENCE 700 1- Fujii Takayuki Department of Nephrology, Seirei Sakura Citizen Hospital, Chiba, Japan aut NATIONALLICENCE 700 1- Kobayashi Eriko Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut NATIONALLICENCE 700 1- Sakurada Tomoya Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut NATIONALLICENCE 700 1- Satoh Nobunori Department of Clinical Education and Research, Graduate School of Pharmaceutical Sciences, Chiba University, Chiba, Japan aut NATIONALLICENCE 700 1- Ueda Shiro Department of Drug Information and Communication, Graduate School of Pharmaceutical Sciences, Chiba University, 1-8-1 Inohana, Chuo-ku, 260-8675, Chiba, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 100-107 1342-1751 15:1<100 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer