caa a22 4500 445882565 CHVBK 20180317145548.0 cr unu---uuuuu 170323e20110201xx s 000 0 eng 10.1007/s10157-010-0349-1 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0349-1 Aggravation of diabetic nephropathy in OLETF rats by Thy-1.1 nephritis [Elektronische Daten] [Maho Watanabe, Hitoshi Nakashima, Katsuhisa Miyake, Toshinobu Sato, Takao Saito] Objective: To clarify whether the induction of Thy-1.1 nephritis aggravates diabetic nephropathy in the Otsuka Long-Evans Tokushima Fatty (OLETF) rat, which is a model of diabetes mellitus. Method: Forty-week-old OLETF rats were divided into 2 groups according to treatment: (1) 1mg/kg body weight of OX7, an anti-Thy1.1 antibody (administered intravenously) (Group T, n=14); (2) 0.9% saline (Group C, n=14). The histological findings for the kidneys and the index of glomerulosclerosis (IGS) were determined 20weeks after administration, and urine and serum chemistry were also assessed. The same procedure was performed as a control in 2 groups of Long-Evans Tokushima Otsuka (LETO) rats (i.e., nondiabetic OLETF rats). Results: The urinary protein excretion values and the levels of serum albumin in the OX7-treated OLETF rats were significantly higher and lower than those in the untreated OLETF rats, respectively. Total cholesterol was significantly increased in the OX7-treated OLETF rats compared with the untreated OLETF rats. In the histological analysis, IGS was significantly higher in the OX7-treated OLETF rats than in the untreated OLETF rats. Neither deteriorations in the laboratory assessment values nor histological alterations were seen in the LETO rats. Conclusion: These findings indicate that an anti-Thy-1.1 antibody irreversibly aggravates diabetic nephropathy in the OLETF rat. Japanese Society of Nephrology, 2010 Diabetic nephropathy nationallicence OLETF rat nationallicence Thy-1.1 nephritis nationallicence Watanabe Maho Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonann-ku, 814-0180, Fukuoka, Japan aut Nakashima Hitoshi Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonann-ku, 814-0180, Fukuoka, Japan aut Miyake Katsuhisa Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonann-ku, 814-0180, Fukuoka, Japan aut Sato Toshinobu Department of Nephrology, Sendai Shakai Hoken Hospital, Sendai, Japan aut Saito Takao Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonann-ku, 814-0180, Fukuoka, Japan aut Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 25-29 1342-1751 15:1<25 2011 15 10157 https://doi.org/10.1007/s10157-010-0349-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0349-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Watanabe Maho Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonann-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Nakashima Hitoshi Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonann-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Miyake Katsuhisa Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonann-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 700 1- Sato Toshinobu Department of Nephrology, Sendai Shakai Hoken Hospital, Sendai, Japan aut NATIONALLICENCE 700 1- Saito Takao Division of Nephrology and Rheumatology, Department of Internal Medicine, Faculty of Medicine, Fukuoka University, 7-45-1 Nanakuma, Jonann-ku, 814-0180, Fukuoka, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/1(2011-02-01), 25-29 1342-1751 15:1<25 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer