caa a22 4500 44588262X CHVBK 20180317145548.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10157-011-0499-9 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0499-9 Renal complications of Castleman's disease: report of two cases and analysis of 75 cases [Elektronische Daten] [Xiang-Gui Yuan, Wen Hu, Fei-Fei Chen, Bin-Feng Huang, Xiao-Ying Zhao] Biopsy-proven renal complications of Castleman's disease (CD) are rare and current knowledge is largely based on sporadic case reports. We reported two more cases, both of which were multicentric CD with hyaline-vascular pathological pattern and presented with chronic renal failure. Case 1 was multicentric CD with renal mesangial proliferative glomerulonephritis complications, and case 2 was multicentric CD with membranoproliferative glomerulonephritis-like complications. Although both were eventually administered corticosteroids combined with cytotoxic drugs, both behaved in an aggressive and relapsing manner. We then made an analysis of 75 cases of biopsy-proven renal complications of CD (including our two cases) which were reported in 51 English literatures from January 1954 to March 2011. We found that the clinical and histological findings of renal complications of CD were heterogeneous. Death was observed in 17% patients after a median follow-up time of 22months (0-204months) since histological diagnosis of renal complications. The estimated 5-year cumulative survival rate was 75%. Better understanding and therapeutic interventions are required in further investigations. Japanese Society of Nephrology, 2011 Giant lymph node hyperplasia nationallicence Castleman's disease nationallicence Kidney disease nationallicence Pathology nationallicence Survival time nationallicence Therapy nationallicence Yuan Xiang-Gui The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University, Hangzhou, China aut Hu Wen The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University, Hangzhou, China aut Chen Fei-Fei Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China aut Huang Bin-Feng The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University, Hangzhou, China aut Zhao Xiao-Ying Department of Hematology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, 310009, Hangzhou, Zhejiang, China aut Clinical and Experimental Nephrology Springer Japan 15/6(2011-12-01), 921-926 1342-1751 15:6<921 2011 15 10157 https://doi.org/10.1007/s10157-011-0499-9 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0499-9 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yuan Xiang-Gui The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University, Hangzhou, China aut NATIONALLICENCE 700 1- Hu Wen The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University, Hangzhou, China aut NATIONALLICENCE 700 1- Chen Fei-Fei Department of Hematology, The First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou, China aut NATIONALLICENCE 700 1- Huang Bin-Feng The Second Affiliated Hospital (Binjiang Branch), School of Medicine, Zhejiang University, Hangzhou, China aut NATIONALLICENCE 700 1- Zhao Xiao-Ying Department of Hematology, The Second Affiliated Hospital, School of Medicine, Zhejiang University, 88 Jiefang Road, 310009, Hangzhou, Zhejiang, China aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/6(2011-12-01), 921-926 1342-1751 15:6<921 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer