caa a22 4500 445882654 CHVBK 20180317145548.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10157-011-0522-1 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0522-1 Effects of nicorandil on the reduction of BNP levels in patients with chronic kidney disease [Elektronische Daten] [Tomonori Kimura, Harumi Kitamura, Kazunori Inoue, Noritaka Kawada, Isao Matsui, Yasuyuki Nagasawa, Yoshitsugu Obi, Maki Shinzawa, Yasuhiko Sakata, Takayuki Hamono, Hiromi Rakugi, Yoshitaka Isaka] Background: Patients with chronic kidney disease (CKD) still frequently experience cardiovascular events despite recent progress in treatment. We examined whether nicorandil, a hybrid nitrate and adenosine triphosphate-sensitive potassium channel opener, could improve a biomarker and physiological markers of cardiovascular events. Methods: Patients with advanced stage CKD (stage III-V with or without peritoneal dialysis) were included in this trial if they were considered at high risk for cardiovascular events [past history of cardiovascular diseases, past history of coronary angiography, presence of endothelial dysfunction measured by reactive hyperemia peripheral arterial tonometry, and presence of high brain natriuretic peptide (BNP) values]. Patients were randomly assigned to be treated with or without oral nicorandil, 15mg/day. BNP values and endothelial function (augmentation index, pulse wave velocity, and reactive hyperemia peripheral arterial tonometry) before and 1month after the initiation of the trial were assessed. Results: Nineteen patients (15 men, 4 women) with a mean age of 61±10 (SD) years were included. The median baseline BNP value was 75.3 (interquartile range, 32.1-138.8) pg/ml, and the BNP level was significantly reduced in the nicorandil group (P<0.05). Regression analysis demonstrated that only the use of nicorandil is related to a decrease of BNP levels [standardized β coefficient, −75.1 (95% CI, −19.7 to −130.6), P=0.01]. There were no significant changes in the rest of the parameters in the nicorandil group in comparison to the control group. The change in BNP levels was correlated with changes in the augmentation index (P<0.01) and central pulse pressure (P=0.03). Conclusions: Nicorandil treatment may reduce the level of BNP by reducing the central blood pressure in CKD patients. Japanese Society of Nephrology, 2011 Nicorandil nationallicence Chronic kidney disease (CKD) nationallicence Peritoneal dialysis (PD) nationallicence Brain natriuretic peptide (BNP) nationallicence Endothelial function nationallicence Kimura Tomonori Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Kitamura Harumi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Inoue Kazunori Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Kawada Noritaka Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Matsui Isao Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Nagasawa Yasuyuki Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Obi Yoshitsugu Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Shinzawa Maki Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Sakata Yasuhiko Department of Cardiology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Hamono Takayuki Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Rakugi Hiromi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Isaka Yoshitaka Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut Clinical and Experimental Nephrology Springer Japan 15/6(2011-12-01), 854-860 1342-1751 15:6<854 2011 15 10157 https://doi.org/10.1007/s10157-011-0522-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0522-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kimura Tomonori Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kitamura Harumi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Inoue Kazunori Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Kawada Noritaka Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Matsui Isao Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Nagasawa Yasuyuki Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Obi Yoshitsugu Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Shinzawa Maki Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Sakata Yasuhiko Department of Cardiology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Hamono Takayuki Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Rakugi Hiromi Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Isaka Yoshitaka Department of Geriatric Medicine and Nephrology, Osaka University Graduate School of Medicine, B6, 2-2 Yamada-oka, 585-0871, Suita, Osaka, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/6(2011-12-01), 854-860 1342-1751 15:6<854 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer