caa a22 4500 445882670 CHVBK 20180317145548.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10157-011-0523-0 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0523-0 Validation of the equations for estimating daily sodium excretion from spot urine in patients with chronic kidney disease [Elektronische Daten] [Enyu Imai, Yoshinari Yasuda, Masaru Horio, Kanako Shibata, Sawako Kato, Yu Mizutani, Junko Imai, Mutsuharu Hayashi, Hideki Kamiya, Yutaka Oiso, Toyoaki Murohara, Shoichi Maruyama, Seiichi Matsuo] Background: Measuring sodium excretion in a 24-h urine collection is the most reliable method of estimating salt intake, but it is not applicable to all patients. As an alternative, equations for estimating Na excretion from Japanese by a spot urine sample were created, but they have not been validated in patients with chronic kidney disease (CKD), which are frequently associated with nocturia and medication. Methods: We enrolled 136 patients with CKD and collected both 24-h urine and the first morning urine. Na excretion was estimated from the first morning urine by Kawasaki's equation, which was originally used for the second morning urine, and Tanaka's equation, which is applied for spot urine samples taken at any time from 9am to 7pm. We evaluated the two equations for bias, RMSE and accuracy within 30 and 50% of the measured Na excretion. Results: Bias, RMSE and accuracy within 30% of the estimated Na excretion were 48±69 and 2±69mmol/day, 84 and 69mmol/day, and 35 and 49% using Kawasaki's equation and Tanaka's equation, respectively. Na excretion in the first morning urine was accurately estimated by Tanaka's equation, but it was overestimated by Kawasaki's equation. Nocturia and medication such as diuretics and ACE inhibitor or angiotensin receptor blocker did not affect the accuracy with which Na excretion was estimated by Tanaka's equation substantially. Conclusion: Tanaka's equation for estimating Na excretion from the first morning urine in patients with CKD is accurate enough for use in clinical practice. Japanese Society of Nephrology, 2011 Sodium nationallicence Creatinine nationallicence CKD nationallicence Estimated Na excretion nationallicence Imai Enyu Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, 466-8550, Nagoya, Japan aut Yasuda Yoshinari Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Horio Masaru Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Japan aut Shibata Kanako Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Kato Sawako Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Mizutani Yu Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Imai Junko Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Hayashi Mutsuharu Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Kamiya Hideki Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Oiso Yutaka Department of Endocrinology and Diabetology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Murohara Toyoaki Departmant of Cardiovascular Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Maruyama Shoichi Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, 466-8550, Nagoya, Japan aut Matsuo Seiichi Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, 466-8550, Nagoya, Japan aut Clinical and Experimental Nephrology Springer-Verlag 15/6(2011-12-01), 861-867 1342-1751 15:6<861 2011 15 10157 https://doi.org/10.1007/s10157-011-0523-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0523-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Imai Enyu Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Yasuda Yoshinari Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Horio Masaru Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, Suita, Japan aut NATIONALLICENCE 700 1- Shibata Kanako Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Kato Sawako Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Mizutani Yu Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Imai Junko Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Hayashi Mutsuharu Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Kamiya Hideki Department of CKD Initiatives, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Oiso Yutaka Department of Endocrinology and Diabetology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Murohara Toyoaki Departmant of Cardiovascular Medicine, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Maruyama Shoichi Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 700 1- Matsuo Seiichi Department of Nephrology, Nagoya University Graduate School of Medicine, 65 Tsurumai, Showa-ku, 466-8550, Nagoya, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer-Verlag 15/6(2011-12-01), 861-867 1342-1751 15:6<861 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer