caa a22 4500 445882697 CHVBK 20180317145549.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10157-011-0512-3 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0512-3 Pioglitazone reduces urinary albumin excretion in renin−angiotensin system inhibitor-treated type 2 diabetic patients with hypertension and microalbuminuria: the APRIME study [Elektronische Daten] [Akizuki Morikawa, Kanaki Ishizeki, Yasunori Iwashima, Hiroki Yokoyama, Eiji Muto, Eiji Oshima, Masatomo Sekiguchi, Takanori Miura, Hiroshi Itoh, Masakazu Haneda] Background: The aim of his study was to compare the efficacy of pioglitazone with metformin on the reduction of albuminuria in type 2 diabetic patients with hypertension and microalbuminuria treated with renin-angiotensin system inhibitors (RAS-Is). Methods: The open-label, randomized trial was performed in type 2 diabetic patients with hypertension and microalbuminuria. On the basis of the treatment with RAS-Is, 68 patients with microalbuminuria received either pioglitazone (15-30mg/day; n=32) or metformin (500-750mg/day; n=31) for 52weeks. Urinary albumin-to-creatinine ratio (UACR) was measured every 12weeks. Results: After 52weeks of treatment, the changes in the log-UACR from baseline were −8.3% in the pioglitazone group and +4.2% in the metformin group (p=0.01), with similar glycemic and blood pressure changes. Conclusion: The combination of pioglitazone and RAS-Is showed therapeutic benefit in the reduction of urinary albumin excretion for type 2 diabetic patients with hypertension and microalbuminuria. Japanese Society of Nephrology, 2011 Diabetic nephropathy nationallicence Microalbuminuria nationallicence Pioglitazone nationallicence Renin-angiotensin system inhibitor nationallicence Morikawa Akizuki Department of Internal Medicine, Asahikawa Red Cross Hospital, Akebono 1-1, 070-8530, Asahikawa, Japan aut Ishizeki Kanaki Department of Medicine, Asahikawa Medical University, Asahikawa, Japan aut Iwashima Yasunori Department of Internal Medicine, Yoshida Hospital, Asahikawa, Japan aut Yokoyama Hiroki Jiyugaoka Medical Clinic, Obihiro, Japan aut Muto Eiji Department of Internal Medicine, Asahikawa City Hospital, Asahikawa, Japan aut Oshima Eiji Oshima Clinic, Asahikawa, Japan aut Sekiguchi Masatomo Department of Internal Medicine, Sapporo-Kosei General Hospital, Sapporo, Japan aut Miura Takanori Department of Internal Medicine, Asahikawa-Kosei General Hospital, Asahikawa, Japan aut Itoh Hiroshi Department of Internal Medicine, Ohotsukukai Hospital, Kitami, Japan aut Haneda Masakazu Department of Medicine, Asahikawa Medical University, Asahikawa, Japan aut Clinical and Experimental Nephrology Springer Japan 15/6(2011-12-01), 848-853 1342-1751 15:6<848 2011 15 10157 https://doi.org/10.1007/s10157-011-0512-3 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0512-3 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morikawa Akizuki Department of Internal Medicine, Asahikawa Red Cross Hospital, Akebono 1-1, 070-8530, Asahikawa, Japan aut NATIONALLICENCE 700 1- Ishizeki Kanaki Department of Medicine, Asahikawa Medical University, Asahikawa, Japan aut NATIONALLICENCE 700 1- Iwashima Yasunori Department of Internal Medicine, Yoshida Hospital, Asahikawa, Japan aut NATIONALLICENCE 700 1- Yokoyama Hiroki Jiyugaoka Medical Clinic, Obihiro, Japan aut NATIONALLICENCE 700 1- Muto Eiji Department of Internal Medicine, Asahikawa City Hospital, Asahikawa, Japan aut NATIONALLICENCE 700 1- Oshima Eiji Oshima Clinic, Asahikawa, Japan aut NATIONALLICENCE 700 1- Sekiguchi Masatomo Department of Internal Medicine, Sapporo-Kosei General Hospital, Sapporo, Japan aut NATIONALLICENCE 700 1- Miura Takanori Department of Internal Medicine, Asahikawa-Kosei General Hospital, Asahikawa, Japan aut NATIONALLICENCE 700 1- Itoh Hiroshi Department of Internal Medicine, Ohotsukukai Hospital, Kitami, Japan aut NATIONALLICENCE 700 1- Haneda Masakazu Department of Medicine, Asahikawa Medical University, Asahikawa, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/6(2011-12-01), 848-853 1342-1751 15:6<848 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer