caa a22 4500 445882786 CHVBK 20180317145549.0 cr unu---uuuuu 170323e20111201xx s 000 0 eng 10.1007/s10157-011-0525-y doi (NATIONALLICENCE)springer-10.1007/s10157-011-0525-y Performance of serum cystatin C versus serum creatinine as a marker of glomerular filtration rate as measured by inulin renal clearance [Elektronische Daten] [Masaru Horio, Enyu Imai, Yoshinari Yasuda, Tsuyoshi Watanabe, Seiichi Matsuo] Introduction: Serum cystatin C was recently proposed as an alternative marker of glomerular filtration rate (GFR), with a suggested better performance than creatinine. However, detailed studies are limited. We evaluated the performance of cystatin C as a GFR marker. Methods: GFR was measured by inulin clearance in 763 Japanese subjects. Factors other than GFR influencing serum cystatin C or serum creatinine were analyzed by multivariate analyses. Results: After adjustment for GFR, the value of serum creatinine was 25.2% lower in females than males, and decreased by 5.2% for every 20years of age. Serum cystatin C was 8.2% lower in females, and did not change significantly with aging. Creatinine but not cystatin C was significantly affected by body weight, height and body mass index after adjustment for GFR, gender and age. The correlation coefficient between GFR and 1/cystatin C was significantly higher than that of 1/creatinine in total subjects (0.866 and 0.810, respectively, p<0.001). Unlike serum creatinine, serum cystatin C did not increase in association with the reduction of GFR in subjects with very low GFR. The regression line of 1/cystatin C against GFR showed a significantly negative intercept of about −8ml/min/1.73m2. Conclusion: The performance of serum cystatin C was not good in the subjects with very low GFR. Non-renal elimination of cystatin C may contribute to the result. The correlation between reciprocal cystatin C and GFR suggested its superiority in predicting GFR compared to creatinine in subjects with normal and mildly reduced GFR. Japanese Society of Nephrology, 2011 Creatinine nationallicence Cystatin C nationallicence Inulin clearance nationallicence Glomerular filtration rate nationallicence Horio Masaru Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut Imai Enyu Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Yasuda Yoshinari Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Watanabe Tsuyoshi Third Department of Medicine, Fukushima Medical University, Fukushima, Japan aut Matsuo Seiichi Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut Clinical and Experimental Nephrology Springer Japan 15/6(2011-12-01), 868-876 1342-1751 15:6<868 2011 15 10157 https://doi.org/10.1007/s10157-011-0525-y text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0525-y text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Horio Masaru Department of Functional Diagnostic Science, Osaka University Graduate School of Medicine, 565-0871, Suita, Osaka, Japan aut NATIONALLICENCE 700 1- Imai Enyu Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Yasuda Yoshinari Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 700 1- Watanabe Tsuyoshi Third Department of Medicine, Fukushima Medical University, Fukushima, Japan aut NATIONALLICENCE 700 1- Matsuo Seiichi Department of Nephrology, Nagoya University Graduate School of Medicine, Nagoya, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/6(2011-12-01), 868-876 1342-1751 15:6<868 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer