caa a22 4500 445882891 CHVBK 20180317145550.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10157-010-0398-5 doi (NATIONALLICENCE)springer-10.1007/s10157-010-0398-5 The association of plasma prorenin level with an oxidative stress marker, 8-OHdG, in nondiabetic hemodialysis patients [Elektronische Daten] [Yoshiyuki Morishita, Shiho Hanawa, Takuya Miki, Taro Sugase, Yasuhiro Sugaya, Junko Chinda, Osamu Iimura, Sadao Tsunematsu, Kenichi Ishibashi, Eiji Kusano] Background: Circulating prorenin contributes to the pathogenesis of tissue damage leading to cardiovascular disease (CVD) in hypertension and diabetic mellitus (DM) by activating the tissue renin-angiotensin-aldosterone (RAS) system; however, little is known about its roles in hemodialysis (HD) patients. Methods: We evaluated plasma prorenin level and prorenin receptor [(P)RR] expression in peripheral blood mononuclear cells (PBMCs) in 49 nondiabetic HD (non-DM-HD) patients. Then we investigated the association between plasma prorenin level or (P)RR expression level in PBMCs and CVD-predictive biomarkers. Results: The plasma prorenin level increased in non-DM-HD patients [147.1±118.9pg/ml (standard value <100pg/ml)]. The (P)RR mRNA expression level in PBMCs also increased 1.41±0.39-fold in non-DM-HD patients compared with that in healthy control subjects (p<0.001). Although plasma prorenin level did not correlate with plasma BNP level and plasma high-sensitivity C-reactive protein level, it significantly correlated with plasma 8-hydroxydeoxyguanosine (8-OHdG) level (r=0.535, p<0.001). The plasma prorenin level did not correlate with plasma renin activity (PRA), plasma angiotensin I (AT I) level, plasma angiotensin II (AT II) level and plasma aldosterone (Ald) level. PRA, plasma AT I level, plasma AT II level and plasma Ald level did not correlate with the level of any CVD predictive biomarker. (P)RR expression level in PBMCs did not correlate with the level of any CVD predictive biomarker. Conclusions: The plasma prorenin level and (P)RR expression level in PBMCs increased, and the plasma prorenin level was associated with plasma 8-OHdG level independent of circulating RAS in non-DM-HD patients. Japanese Society of Nephrology, 2011 Prorenin nationallicence Hemodialysis patients nationallicence Biomarker for cardiovascular disease nationallicence Morishita Yoshiyuki Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Hanawa Shiho Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Miki Takuya Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Sugase Taro Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Sugaya Yasuhiro Ninomiya Central Clinic, Tochigi, Japan aut Chinda Junko Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Iimura Osamu Kumakura Clinic, Tochigi, Japan aut Tsunematsu Sadao Yuki Clinic, Ibaraki, Japan aut Ishibashi Kenichi Department of Medical Physiology, Meiji Pharmaceutical University, Tokyo, Japan aut Kusano Eiji Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Clinical and Experimental Nephrology Springer Japan 15/3(2011-06-01), 398-404 1342-1751 15:3<398 2011 15 10157 https://doi.org/10.1007/s10157-010-0398-5 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-010-0398-5 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Morishita Yoshiyuki Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Hanawa Shiho Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Miki Takuya Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Sugase Taro Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Sugaya Yasuhiro Ninomiya Central Clinic, Tochigi, Japan aut NATIONALLICENCE 700 1- Chinda Junko Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Iimura Osamu Kumakura Clinic, Tochigi, Japan aut NATIONALLICENCE 700 1- Tsunematsu Sadao Yuki Clinic, Ibaraki, Japan aut NATIONALLICENCE 700 1- Ishibashi Kenichi Department of Medical Physiology, Meiji Pharmaceutical University, Tokyo, Japan aut NATIONALLICENCE 700 1- Kusano Eiji Division of Nephrology, Department of Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/3(2011-06-01), 398-404 1342-1751 15:3<398 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer