caa a22 4500 445882913 CHVBK 20180317145550.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10157-011-0418-0 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0418-0 Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes [Elektronische Daten] [Shiro Maeda, Daisuke Koya, Shin-ichi Araki, Tetsuya Babazono, Tomoya Umezono, Masao Toyoda, Koichi Kawai, Masahito Imanishi, Takashi Uzu, Daisuke Suzuki, Hiroshi Maegawa, Atsunori Kashiwagi, Yasuhiko Iwamoto, Yusuke Nakamura] Background: Sirtuin is a member of the nicotinamide adenine dinucleotide (NAD)-dependent deacetylases, and has been reported to play a pivotal role in energy expenditure, mitochondrial function and pathogenesis of metabolic diseases, including aging kidneys. In this study, we focused on the genes encoding sirtuin families, and examined the association between single nucleotide polymorphisms (SNPs) within genes encoding sirtuin families and diabetic nephropathy. Methods: We examined 52 SNPs within the SIRT genes (11 in SIRT1, 7 in SIRT2, 14 in SIRT3, 7 in SIRT4, 9 in SIRT5, and 4 in SIRT6) in 3 independent Japanese populations with type 2 diabetes (study 1: 747 cases (overt proteinuria), 557 controls; study 2: 455 cases (overt proteinuria) and 965 controls; study 3: 300 cases (end-stage renal disease) and 218 controls). The associations between these SNPs were analyzed by the Cochran-Armitage trend test, and results of the 3 studies were combined with a meta-analysis. We further examined an independent cohort (195 proteinuria cases and 264 controls) for validation of the original association. Results: We identified 4 SNPs in SIRT1 that were nominally associated with diabetic nephropathy (P<0.05), and subsequent haplotype analysis revealed that a haplotype consisting of the 11 SNPs within SIRT1 locus had a stronger association (P=0.0028). Conclusion: These results indicate that SIRT1 may play a role in susceptibility to diabetic nephropathy in Japanese subjects with type 2 diabetes. Japanese Society of Nephrology, 2011 Single nucleotide polymorphism (SNP) nationallicence Association study nationallicence SIRT1 nationallicence Diabetic nephropathy nationallicence Maeda Shiro Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Kanagawa, Japan aut Koya Daisuke Division of Endocrinology and Metabolism, Kanazawa Medical University, Ishikawa, Japan aut Araki Shin-ichi Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan aut Babazono Tetsuya The Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan aut Umezono Tomoya Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan aut Toyoda Masao Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan aut Kawai Koichi Kawai Clinic, Ibaraki, Japan aut Imanishi Masahito Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan aut Uzu Takashi Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan aut Suzuki Daisuke Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan aut Maegawa Hiroshi Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan aut Kashiwagi Atsunori Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan aut Iwamoto Yasuhiko The Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan aut Nakamura Yusuke Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 108-8639, Tokyo, Japan aut Clinical and Experimental Nephrology Springer Japan 15/3(2011-06-01), 381-390 1342-1751 15:3<381 2011 15 10157 https://doi.org/10.1007/s10157-011-0418-0 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0418-0 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Maeda Shiro Laboratory for Endocrinology and Metabolism, RIKEN Center for Genomic Medicine, 1-7-22 Suehiro-cho, Tsurumi-ku, 230-0045, Yokohama, Kanagawa, Japan aut NATIONALLICENCE 700 1- Koya Daisuke Division of Endocrinology and Metabolism, Kanazawa Medical University, Ishikawa, Japan aut NATIONALLICENCE 700 1- Araki Shin-ichi Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan aut NATIONALLICENCE 700 1- Babazono Tetsuya The Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan aut NATIONALLICENCE 700 1- Umezono Tomoya Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Toyoda Masao Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Kawai Koichi Kawai Clinic, Ibaraki, Japan aut NATIONALLICENCE 700 1- Imanishi Masahito Department of Internal Medicine, Osaka City General Hospital, Osaka, Japan aut NATIONALLICENCE 700 1- Uzu Takashi Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan aut NATIONALLICENCE 700 1- Suzuki Daisuke Division of Nephrology and Metabolism, Department of Internal Medicine, Tokai University School of Medicine, Isehara, Kanagawa, Japan aut NATIONALLICENCE 700 1- Maegawa Hiroshi Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan aut NATIONALLICENCE 700 1- Kashiwagi Atsunori Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan aut NATIONALLICENCE 700 1- Iwamoto Yasuhiko The Diabetes Center, Tokyo Women's Medical University, Tokyo, Japan aut NATIONALLICENCE 700 1- Nakamura Yusuke Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, 108-8639, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/3(2011-06-01), 381-390 1342-1751 15:3<381 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer