caa a22 4500 445883014 CHVBK 20180317145550.0 cr unu---uuuuu 170323e20110601xx s 000 0 eng 10.1007/s10157-011-0419-z doi (NATIONALLICENCE)springer-10.1007/s10157-011-0419-z A case of slowly progressive scleroderma kidney [Elektronische Daten] [Masahiro Okabe, Nobuo Tsuboi, Takahide Suzuki, Takashi Yokoo, Yoichi Miyazaki, Yasunori Utsunomiya, Iwao Ohno, Tatsuo Hosoya] A rapidly progressive renal deterioration accompanied by acute-onset/uncontrolled hypertension characterizes scleroderma renal crisis (SRC), a life-threatening complication that occurs in patients with systemic sclerosis (SSc). To date, however, SSc with advanced renal failure has only rarely been reported in the absence of SRC. We report here an atypical case of diffuse cutaneous SSc where renal insufficiency progressed slowly to end-stage renal failure over a 14-year follow-up period after the diagnosis of SSc. In the renal biopsy, which was obtained at a relatively early stage of renal impairment, we found histological findings consistent with those of scleroderma kidneys. Unlike typical SRC, however, the larger renal arteries seemed to be unaffected. These histological findings were probably responsible for the "slowly progressive” renal impairment over the years without causing typical SRC. Japanese Society of Nephrology, 2011 Systemic sclerosis nationallicence Scleroderma renal crisis nationallicence Chronic forms nationallicence Renin-angiotensin system inhibitors nationallicence Okabe Masahiro Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Tsuboi Nobuo Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Suzuki Takahide Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Yokoo Takashi Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Miyazaki Yoichi Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Utsunomiya Yasunori Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Ohno Iwao Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Hosoya Tatsuo Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut Clinical and Experimental Nephrology Springer Japan 15/3(2011-06-01), 430-433 1342-1751 15:3<430 2011 15 10157 https://doi.org/10.1007/s10157-011-0419-z text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0419-z text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Okabe Masahiro Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Tsuboi Nobuo Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Suzuki Takahide Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Yokoo Takashi Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Miyazaki Yoichi Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Utsunomiya Yasunori Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Ohno Iwao Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 700 1- Hosoya Tatsuo Division of Kidney and Hypertension, Department of Internal Medicine, The Jikei University School of Medicine, 3-25-8 Nishi-Shimbashi, Minato-Ku, 105-8461, Tokyo, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/3(2011-06-01), 430-433 1342-1751 15:3<430 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer