caa a22 4500 44588312X CHVBK 20180317145550.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0432-2 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0432-2 Myeloperoxidase-antineutrophil cytoplasmic antibody-related crescentic glomerulonephritis after treatment for clinically amyopathic dermatomyositis: a coincidental combination or not? [Elektronische Daten] [Hirohisa Kawai, Wataru Kitagawa, Natsuko Suzuki, Kunihiro Maeda, Keisuke Suzuki, Naoto Miura, Hiroyuki Morita, Syogo Banno, Masahiro Yamamura, Hirokazu Imai] A 60-year-old Japanese man exhibited rapidly progressive glomerulonephritis 10years after receiving prednisolone therapy for clinically amyopathic dermatomyositis (CADM). Upon admission, there were no signs of dermatomyositis. Laboratory analyses revealed the presence of myeloperoxidase-antineutrophil cytoplasmic antibodies (MPO-ANCA) at 1,280 EU in the absence of anti-glomerular basement membrane antibody and anti-melanoma differentiation-associated gene 5 antibodies, which are typically expressed in CADM. A renal biopsy demonstrated that 14 of 29 glomeruli showed global sclerosis, and the remaining 15 glomeruli exhibited fibrotic and fibrocellular crescent formation without immunoglobulin and complement. Following treatment with 500mg/day methylprednisolone pulse therapy for 3days, the patient was started on 30mg/day of prednisolone orally. On the third day of hospitalization, we began hemodialysis for uremia and anuria with three treatments of plasma exchange starting on the tenth hospital day. Unfortunately, the patient's renal function did not recover, despite decreases in CRP and MPO-ANCA levels to the normal range. This case is the first English language report of MPO-ANCA-related crescentic glomerulonephritis in a patient who had recovered from CADM. Japanese Society of Nephrology, 2011 Crescentic glomerulonephritis nationallicence Clinically amyopathic dermatomyositis (CADM) nationallicence Myeloperoxidase-antineutrophil cytoplasmic antibody (MPO-ANCA) nationallicence Kawai Hirohisa Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Kitagawa Wataru Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Suzuki Natsuko Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Maeda Kunihiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Suzuki Keisuke Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Miura Naoto Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Morita Hiroyuki Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Banno Syogo Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Yamamura Masahiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Imai Hirokazu Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 577-581 1342-1751 15:4<577 2011 15 10157 https://doi.org/10.1007/s10157-011-0432-2 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0432-2 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Kawai Hirohisa Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Kitagawa Wataru Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Suzuki Natsuko Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Maeda Kunihiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Suzuki Keisuke Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Miura Naoto Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Morita Hiroyuki Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Banno Syogo Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Yamamura Masahiro Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 700 1- Imai Hirokazu Division of Nephrology and Rheumatology, Department of Internal Medicine, Aichi Medical University School of Medicine, Nagakute-cyo, 480-1195, Aichi, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 577-581 1342-1751 15:4<577 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer