caa a22 4500 445883162 CHVBK 20180317145551.0 cr unu---uuuuu 170323e20110801xx s 000 0 eng 10.1007/s10157-011-0425-1 doi (NATIONALLICENCE)springer-10.1007/s10157-011-0425-1 Nephrotic syndrome and renal failure in a patient with metastatic breast cancer [Elektronische Daten] [Hiromichi Yoshizawa, Tetsu Akimoto, Katsuhiko Nishino, Makoto Inoue, Chiharu Ito, Shinichi Takeda, Atsushi Kotoda, Kaichiro Tamba, Wako Yumura, Shigeaki Muto, Yoshihiko Ueda, Eiji Kusano] This report presents a case of nephrotic syndrome and renal failure that developed in a 53-year-old female with metastatic breast carcinoma. She was diagnosed to have osteolytic bone metastases 5years prior to admission, and had been administered pamidronate with a total dose of approximately 6800mg. A renal biopsy revealed tubulointerstitial damage and marked wrinkling and retraction of the glomerular basement membrane with hypertrophy and hyperplasia of the epithelial cells, compatible with the collapsing form of focal segmental glomerulosclerosis (FSGS). Despite the discontinuation of pamidronate after admission, her renal function gradually decreased. She was finally managed with continuous palliative care for advanced malignancy through a shared effort, and died 96days after undergoing the renal biopsy. Although the clinical impact of the pamidronate-associated kidney injury on the longitudinal changes in renal function remains to be delineated, it is therefore reasonable to consider that the collapsing FSGS associated with tubulointerstitial damage may have resulted in the irreversible renal injuries that were observed in the current case. Further studies and accumulated experience with renal biopsy are required to better determine the relationship between pathological alterations and prognostic characteristics among patients with pamidronate-associated renal impairments. Japanese Society of Nephrology, 2011 Pamidronate nationallicence Nephrotic syndrome nationallicence Breast cancer nationallicence Collapsing focal segmental glomerulosclerosis nationallicence Parietal epithelial cells nationallicence Yoshizawa Hiromichi Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Akimoto Tetsu Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Nishino Katsuhiko Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Inoue Makoto Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Ito Chiharu Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Takeda Shinichi Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Kotoda Atsushi Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Tamba Kaichiro Department of Palliative Care Medicine, Jichi Medical University, Tochigi, Japan aut Yumura Wako Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Muto Shigeaki Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Ueda Yoshihiko Department of Diagnostic Pathology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan aut Kusano Eiji Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 567-571 1342-1751 15:4<567 2011 15 10157 https://doi.org/10.1007/s10157-011-0425-1 text/html Onlinezugriff via DOI 1 research-article jats NATIONALLICENCE 856 40 https://doi.org/10.1007/s10157-011-0425-1 text/html Onlinezugriff via DOI NATIONALLICENCE 700 1- Yoshizawa Hiromichi Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Akimoto Tetsu Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Nishino Katsuhiko Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Inoue Makoto Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Ito Chiharu Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Takeda Shinichi Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Kotoda Atsushi Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Tamba Kaichiro Department of Palliative Care Medicine, Jichi Medical University, Tochigi, Japan aut NATIONALLICENCE 700 1- Yumura Wako Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Muto Shigeaki Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 700 1- Ueda Yoshihiko Department of Diagnostic Pathology, Dokkyo Medical University Koshigaya Hospital, Saitama, Japan aut NATIONALLICENCE 700 1- Kusano Eiji Division of Nephrology, Department of Internal Medicine, Jichi Medical University, 3311-1 Yakushiji, 329-0498, Shimotsuke, Tochigi, Japan aut NATIONALLICENCE 773 0- Clinical and Experimental Nephrology Springer Japan 15/4(2011-08-01), 567-571 1342-1751 15:4<567 2011 15 10157 Metadata rights reserved Springer special CC-BY-NC licence nationallicence BK010053 XK010053 XK010000 NATIONALLICENCE NATIONALLICENCE NL-springer